What is the NOAEL for 1,4-Cyclohexanedicarboxylic acid?
1,4-Cyclohexanedicarboxylic acid has 14 NOAEL studies in the database. The lowest reported value is 20.57 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,4-Cyclohexanedicarboxylic acid
Also known as: 1,4-Dicarboxycyclohexane, EINECS 214-068-6, Hexahydroterephthalic acid, Terephthalic acid, hexahydro-, UNII-13LBH83IU4
CAS 1076-97-7
1,4-Cyclohexanedicarboxylic acid (CAS 1076-97-7) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for 1,4-Cyclohexanedicarboxylic Acid →
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
1,4-Cyclohexanedicarboxylic acid
CAS Number
1076-97-7
DTXSID
DTXSID2038788
Molecular Formula
C8H12O4
InChI Key
PXGZQGDTEZPERC-UHFFFAOYSA-N
Monoisotopic Mass
172.073559
Synonyms
1,4-DicarboxycyclohexaneEINECS 214-068-6Hexahydroterephthalic acidTerephthalic acid, hexahydro-UNII-13LBH83IU4
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
No specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =20.57 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 13LBH83IU4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 13LBH83IU4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 13LBH83IU4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 13LBH83IU4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1903 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2263 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 885 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 249 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=871 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=894 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cyclohexane-1,4-dicarboxylic acid | 214-068-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1,4-Cyclohexanedicarboxylic acid?
1,4-Cyclohexanedicarboxylic acid appears on 2 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is 1,4-Cyclohexanedicarboxylic acid used in cosmetics?
Yes, 1,4-Cyclohexanedicarboxylic acid is also indexed as a cosmetic ingredient under the name 1,4-Cyclohexanedicarboxylic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,4-Cyclohexanedicarboxylic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,4-Cyclohexanedicarboxylic acid used outside industrial chemicals?
1,4-Cyclohexanedicarboxylic acid also appears in cosmetics, cannabis databases.