What is the NOAEL for Hexanedihydrazide?
Hexanedihydrazide has 10 NOAEL studies in the database. The lowest reported value is 0.6018 uL/min/10^6 cells in Human. Source: NTP ICE adme parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Hexanedihydrazide
Also known as: Hexanedioic acid, dihydrazide, EINECS 213-999-5
CAS 1071-93-8
Hexanedihydrazide (CAS 1071-93-8) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Hexanedihydrazide is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H411, H320, H361, H400, H410).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
10
SOURCE
Chemical inventory jurisdictions
Regulatory lists
0
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
Hexanedihydrazide
CAS Number
1071-93-8
DTXSID
DTXSID0044361
Molecular Formula
C6H14N4O2
InChI Key
IBVAQQYNSHJXBV-UHFFFAOYSA-N
Monoisotopic Mass
174.111676
Synonyms
Hexanedioic acid, dihydrazideEINECS 213-999-5
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
17 records
DeodorizerProcessing aids not otherwise specifiedNo specific technical functionChemical reaction regulatorViscosity modifierHardenerHumectant
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.6018 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| =17.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| VK98I9YW5M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VK98I9YW5M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VK98I9YW5M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VK98I9YW5M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.9601 | fraction | Fu | - | Human | NTP ICE adme parameters |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =85 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB HESS |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Adipohydrazide | 213-999-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL3185968
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
Is Hexanedihydrazide used in cosmetics?
Yes, Hexanedihydrazide is also indexed as a cosmetic ingredient under the name Adipic Acid Dihydrazide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hexanedihydrazide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Hexanedihydrazide have different safety status in cosmetics vs industrial chemicals?
Hexanedihydrazide is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H411, H320, H361, H400, H410).
Is Hexanedihydrazide used outside industrial chemicals?
Hexanedihydrazide also appears in cosmetics, pharmaceutical, cannabis databases.