Warning GHS02GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

1-Methoxy-2-propanol

Also known as: Propylene glycol monomethyl ether, 3-01-00-02146, BRN 1731270, EINECS 203-539-1, Methyl proxitol (+5 more)

CAS 107-98-2

1-Methoxy-2-propanol (CAS 107-98-2) is a chemical substance with GHS signal word Warning; key hazard signal: H226; H336. Key regulatory status: REACH registered, 31 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Methoxyisopropanol →

SOURCE noael studies public
NOAEL studies
42
SOURCE chemical inventory jurisdictions
Regulatory lists
31
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields
Name
1-Methoxy-2-propanol
CAS Number
107-98-2
DTXSID
DTXSID8024284
Molecular Formula
C4H10O2
InChI Key
ARXJGSRGQADJSQ-UHFFFAOYSA-N
Monoisotopic Mass
90.06808
Synonyms
Propylene glycol monomethyl ether3-01-00-02146BRN 1731270EINECS 203-539-1Methyl proxitolPoly-Solve MPMPropasol solvent MUcar Solvent LM (Obs.)UNII-74Z7JO8V3UPM glycol ether

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Flam. Liq. 3; STOT SE 3H226; H336GHS02; GHS07Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe substance and the vapour in high concentrations are irritating to the eyes, skin and respiratory tract. Exposure to very high concentrations could cause depression of the central nervous system.
Long-term EffectsThe substance defats the skin, which may cause dryness or cracking.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its aerosol or vapour, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 6 records
AgencyMetricValueppmmg/m3Skin
NIOSHTWA100 ppm (360 mg/m³)100360N
NIOSHSTEL150 ppm (540 mg/m³)150540N
ACGIHTWA50 ppm [2012]50-N
ACGIHSTEL100 ppm [2012]100-N
CAL/OSHATWA100 ppm (360 mg/m³)100360Y
CAL/OSHASTEL150 ppm (540 mg/m³)150540Y

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 44 records
SolventFragranceViscosity modifierSurfactant (surface active agent)No specific technical functionCoalescing agentDispersing agentChemical reaction regulatorSolubility enhancer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 31 records
ListKeywordSource
detected; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
detected; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
inert_ingredient; non_food_use; PesticidesEPACPCat
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - shoes; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - shoes; EuropeDanish Environmental Protection AgencyDanish EPA
artificial_saliva; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
SCIL (9/2019)USEPASafer Chemical Ingredients List
IFRA TransparencyIFRAIFRA
consumer_productP&GProctor & Gamble
Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
fracking; waterNY Department of ConservationCPCat
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 42 of 42 studies
ValueUnitEndpointRouteSpeciesSource
4.02454312806494uMAC50--NTP_ICE_endocrine
1.84602121758122uMACC--NTP_ICE_endocrine
=369mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
74Z7JO8V3UUNIIFDA UNII substance identifier--openFDA substances
74Z7JO8V3UUNIIFDA UNII substance identifier--openFDA substances
74Z7JO8V3UUNIIFDA UNII substance identifier--openFDA substances
74Z7JO8V3UUNIIFDA UNII substance identifier--openFDA substances
>25.7857mg/LLC50Inhalation-NTP_ICE_acute_inhalation
36.8368mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=58975.8mg/m3LELinhalationHumanToxValDB_DOE_Protective_Action_Criteria
=2757mg/kg bw/dayLOAELoralRatToxValDB_ECHA_IUCLID
=3676mg/kg bw/dayLOAELdermalRabbitToxValDB_ECHA_IUCLID
=11060mg/m3LOAELinhalationRatToxValDB_IRIS
=1975mg/m3LOAEL (ADJ)inhalationRatToxValDB_IRIS
-unitlessModel Score--NTP_ICE_endocrine
0.0156unitlessModel Score--NTP_ICE_endocrine
=3685.99mg/m3NOAECinhalationMouseToxValDB_ECHA_IUCLID
=9214.97mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=18429.9mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=552.898mg/m3NOAELinhalationHumanToxValDB_EU_SCOEL
=919mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
>1000mg/kg bw/dayNOAELdermalRabbitToxValDB_ECHA_IUCLID
=1105.8mg/m3NOAELinhalationRatToxValDB_Cal_OEHHA_REL_derivations
=1105.8mg/m3NOAELinhalationRatToxValDB_ECHA_IUCLID
=1838mg/kg bw/dayNOAELdermalRabbitToxValDB_ECHA_IUCLID
=1885mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
>=2211.59mg/m3NOAELinhalationRatToxValDB_ECHA_IUCLID
>2948.79mg/m3NOAELinhalationRabbitToxValDB_ECHA_IUCLID
=3678mg/m3NOAELinhalationRatToxValDB_IRIS
=3685.99mg/m3NOAELinhalationMouseToxValDB_ECHA_IUCLID
=4600mg/kg bw/dayNOAELdermalRabbitToxValDB_ECHA_IUCLID
=5528.98mg/m3NOAELinhalationRatToxValDB_ECHA_IUCLID
=11058mg/m3NOAELinhalationRabbitToxValDB_ECHA_IUCLID
=658mg/m3NOAEL (ADJ)inhalationRatToxValDB_IRIS
=658mg/m^3NOAEL (HEC)inhalation-EPA_IRIS_iris_rfc_systems.csv
=2%NOELoralMouseToxValDB_ECOTOX
=11058mg/m3NOELinhalationRatToxValDB_ECHA_IUCLID
=2mg/m3RfCinhalationHumanToxValDB_IRIS
=2mg/m^3RfCinhalation-EPA_IRIS_iris_rfc_systems.csv
=20mg/m3RfCinhalationHumanToxValDB_RSL
=0.7mg/kg bw/dayRfDoralHumanToxValDB_RSL
=7mg/kg bw/dayRfDoralHumanToxValDB_RSL

Showing 42 of 42 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered1-methoxypropan-2-ol203-539-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3186306
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 1-Methoxy-2-propanol?

1-Methoxy-2-propanol (CAS 107-98-2) is classified under EU CLP Annex VI as Flam. Liq. 3; STOT SE 3 with signal word Warning. Hazard statements: H226; H336. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1-Methoxy-2-propanol?

1-Methoxy-2-propanol has 42 NOAEL studies in the database. The lowest reported value is 1.84602121758122 uM. Source: NTP_ICE_endocrine.

What regulatory lists include 1-Methoxy-2-propanol?

1-Methoxy-2-propanol appears on 13 regulatory/inventory lists including detected; Europe; Vehicle - car interior, air; detected; emissions; Europe; Toys and children's products, inert_ingredient; non_food_use; Pesticides, and 10 more. Source: EPA CPDat.

What are the occupational exposure limits for 1-Methoxy-2-propanol?

Occupational exposure limits for 1-Methoxy-2-propanol are set by NIOSH, ACGIH, CAL/OSHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 1-Methoxy-2-propanol used in cosmetics?

Yes, 1-Methoxy-2-propanol is also indexed as a cosmetic ingredient under the name Methoxyisopropanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-Methoxy-2-propanol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 1-Methoxy-2-propanol used outside industrial chemicals?

1-Methoxy-2-propanol also appears in cosmetics, pharmaceutical databases.