Warning GHS02GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

1-Methoxy-2-propanol

Also known as: Propylene glycol monomethyl ether, 3-01-00-02146, BRN 1731270, EINECS 203-539-1, Methyl proxitol (+5 more)

CAS 107-98-2

1-Methoxy-2-propanol (CAS 107-98-2) is a chemical substance with GHS signal word Warning; key hazard signal: H226; H336. Key regulatory status: REACH registered, 31 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Methoxyisopropanol →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields

Name

1-Methoxy-2-propanol

CAS Number

107-98-2

DTXSID

DTXSID8024284

Molecular Formula

C4H10O2

InChI Key

ARXJGSRGQADJSQ-UHFFFAOYSA-N

Monoisotopic Mass

90.06808

Synonyms

Propylene glycol monomethyl ether3-01-00-02146BRN 1731270EINECS 203-539-1Methyl proxitolPoly-Solve MPMPropasol solvent MUcar Solvent LM (Obs.)UNII-74Z7JO8V3UPM glycol ether

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 3; STOT SE 3	H226; H336	GHS02; GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance and the vapour in high concentrations are irritating to the eyes, skin and respiratory tract. Exposure to very high concentrations could cause depression of the central nervous system.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol or vapour, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 6 records

Agency	Metric	Value	ppm	mg/m3	Skin
NIOSH	TWA	100 ppm (360 mg/m³)	100	360	N
NIOSH	STEL	150 ppm (540 mg/m³)	150	540	N
ACGIH	TWA	50 ppm [2012]	50	-	N
ACGIH	STEL	100 ppm [2012]	100	-	N
CAL/OSHA	TWA	100 ppm (360 mg/m³)	100	360	Y
CAL/OSHA	STEL	150 ppm (540 mg/m³)	150	540	Y

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 44 records

SolventFragranceViscosity modifierSurfactant (surface active agent)No specific technical functionCoalescing agentDispersing agentChemical reaction regulatorSolubility enhancer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 31 records

List	Keyword	Source
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - shoes; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - shoes; Europe	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
IFRA Transparency	IFRA	IFRA
consumer_product	P&G	Proctor & Gamble
Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
fracking; water	NY Department of Conservation	CPCat
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 42 of 42 studies

Value	Unit	Endpoint	Route	Species	Source
4.02454312806494	uM	AC50	-	-	NTP_ICE_endocrine
1.84602121758122	uM	ACC	-	-	NTP_ICE_endocrine
=369	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
74Z7JO8V3U	UNII	FDA UNII substance identifier	-	-	openFDA substances
74Z7JO8V3U	UNII	FDA UNII substance identifier	-	-	openFDA substances
74Z7JO8V3U	UNII	FDA UNII substance identifier	-	-	openFDA substances
74Z7JO8V3U	UNII	FDA UNII substance identifier	-	-	openFDA substances
>25.7857	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
36.8368	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=58975.8	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=2757	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=3676	mg/kg bw/day	LOAEL	dermal	Rabbit	ToxValDB_ECHA_IUCLID
=11060	mg/m3	LOAEL	inhalation	Rat	ToxValDB_IRIS
=1975	mg/m3	LOAEL (ADJ)	inhalation	Rat	ToxValDB_IRIS
-	unitless	Model Score	-	-	NTP_ICE_endocrine
0.0156	unitless	Model Score	-	-	NTP_ICE_endocrine
=3685.99	mg/m3	NOAEC	inhalation	Mouse	ToxValDB_ECHA_IUCLID
=9214.97	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=18429.9	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=552.898	mg/m3	NOAEL	inhalation	Human	ToxValDB_EU_SCOEL
=919	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>1000	mg/kg bw/day	NOAEL	dermal	Rabbit	ToxValDB_ECHA_IUCLID
=1105.8	mg/m3	NOAEL	inhalation	Rat	ToxValDB_Cal_OEHHA_REL_derivations
=1105.8	mg/m3	NOAEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=1838	mg/kg bw/day	NOAEL	dermal	Rabbit	ToxValDB_ECHA_IUCLID
=1885	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
>=2211.59	mg/m3	NOAEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
>2948.79	mg/m3	NOAEL	inhalation	Rabbit	ToxValDB_ECHA_IUCLID
=3678	mg/m3	NOAEL	inhalation	Rat	ToxValDB_IRIS
=3685.99	mg/m3	NOAEL	inhalation	Mouse	ToxValDB_ECHA_IUCLID
=4600	mg/kg bw/day	NOAEL	dermal	Rabbit	ToxValDB_ECHA_IUCLID
=5528.98	mg/m3	NOAEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=11058	mg/m3	NOAEL	inhalation	Rabbit	ToxValDB_ECHA_IUCLID
=658	mg/m3	NOAEL (ADJ)	inhalation	Rat	ToxValDB_IRIS
=658	mg/m^3	NOAEL (HEC)	inhalation	-	EPA_IRIS_iris_rfc_systems.csv
=2	%	NOEL	oral	Mouse	ToxValDB_ECOTOX
=11058	mg/m3	NOEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=2	mg/m3	RfC	inhalation	Human	ToxValDB_IRIS
=2	mg/m^3	RfC	inhalation	-	EPA_IRIS_iris_rfc_systems.csv
=20	mg/m3	RfC	inhalation	Human	ToxValDB_RSL
=0.7	mg/kg bw/day	RfD	oral	Human	ToxValDB_RSL
=7	mg/kg bw/day	RfD	oral	Human	ToxValDB_RSL

Showing 42 of 42 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	1-methoxypropan-2-ol	203-539-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3186306

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 1-Methoxy-2-propanol?

1-Methoxy-2-propanol (CAS 107-98-2) is classified under EU CLP Annex VI as Flam. Liq. 3; STOT SE 3 with signal word Warning. Hazard statements: H226; H336. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1-Methoxy-2-propanol?

1-Methoxy-2-propanol has 42 NOAEL studies in the database. The lowest reported value is 1.84602121758122 uM. Source: NTP_ICE_endocrine.

What regulatory lists include 1-Methoxy-2-propanol?

1-Methoxy-2-propanol appears on 13 regulatory/inventory lists including detected; Europe; Vehicle - car interior, air; detected; emissions; Europe; Toys and children's products, inert_ingredient; non_food_use; Pesticides, and 10 more. Source: EPA CPDat.

What are the occupational exposure limits for 1-Methoxy-2-propanol?

Occupational exposure limits for 1-Methoxy-2-propanol are set by NIOSH, ACGIH, CAL/OSHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 1-Methoxy-2-propanol used in cosmetics?

Yes, 1-Methoxy-2-propanol is also indexed as a cosmetic ingredient under the name Methoxyisopropanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-Methoxy-2-propanol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 1-Methoxy-2-propanol used outside industrial chemicals?

1-Methoxy-2-propanol also appears in cosmetics, pharmaceutical databases.