What is the NOAEL for 1,3-Butanediol?
1,3-Butanediol has 29 NOAEL studies in the database. The lowest reported value is 4 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,3-Butanediol
Also known as: 1,3-Butylene glycol, 0-01-00-00477, BRN 1731276, Caswell No. 128GG, EINECS 203-529-7 (+8 more)
CAS 107-88-0
1,3-Butanediol (CAS 107-88-0) is a chemical substance. Key regulatory status: REACH registered, 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
29
SOURCE
chemical inventory jurisdictions
Regulatory lists
18
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
1,3-Butanediol
CAS Number
107-88-0
DTXSID
DTXSID8026773
Molecular Formula
C4H10O2
InChI Key
PUPZLCDOIYMWBV-UHFFFAOYSA-N
Monoisotopic Mass
90.06808
Synonyms
1,3-Butylene glycol0-01-00-00477BRN 1731276Caswell No. 128GGEINECS 203-529-7(RS)-1,3-ButandiolUNII-3XUS85K0RANSC-4021451,3 Butylene glycol1,3-Butandiol1,3-ButylenglykolMethyltrimethylene glycol
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
SolventSoftener and conditionerHumectantDeodorizerViscosity modifierFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
18 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 29 of 29 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=4 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| <=4 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| <=4 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 3XUS85K0RA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3XUS85K0RA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3XUS85K0RA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3XUS85K0RA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =0.5 | - | NOAEL | oral (dietary) | rat | CIR_vision_codex |
| =0.5 | - | NOAEL | oral (dietary) | rat | CIR_vision_codex |
| =0.5 | - | NOAEL | oral (dietary) | rat | CIR_vision_codex |
| =0.5 | - | NOAEL | oral (dietary) | rat | CIR_vision_codex |
| =0.6 | - | NOAEL | oral (dietary) | mouse | CIR_vision_codex |
| =0.6 | - | NOAEL | oral (dietary) | mouse | CIR_vision_codex |
| =0.6 | - | NOAEL | oral (dietary) | mouse | CIR_vision_codex |
| =0.6 | - | NOAEL | oral (dietary) | mouse | CIR_vision_codex |
| =167 | - | NOAEL | oral | pig | CIR_vision_codex |
| =167 | - | NOAEL | oral | pig | CIR_vision_codex |
| =167 | - | NOAEL | oral | pig | CIR_vision_codex |
| =167 | - | NOAEL | oral | pig | CIR_vision_codex |
| =500 | mg/kg | NOAEL | oral | rat | CIR_vision_codex |
| =500 | mg/kg | NOAEL | oral | rat | CIR_vision_codex |
| =500 | mg/kg | NOAEL | oral | rat | CIR_vision_codex |
| =500 | mg/kg | NOAEL | oral | rat | CIR_vision_codex |
| 750 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 6000 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 7060 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 10000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 29 of 29 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Butane-1,3-diol | 203-529-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
humectant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3186475
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1,3-Butanediol?
1,3-Butanediol appears on 10 regulatory/inventory lists including air; detected; emissions; Europe; Other direct contact consumer goods, IFRA Transparency, SCIL (9/2019), and 7 more. Source: EPA CPDat.
Is 1,3-Butanediol used in cosmetics?
Yes, 1,3-Butanediol is also indexed as a cosmetic ingredient under the name Butylene Glycol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,3-Butanediol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,3-Butanediol used outside industrial chemicals?
1,3-Butanediol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.