Warning GHS07 NOAEL Data Prop 65 REACH Registered Cosmetic Ingredient

Ethylene glycol

Also known as: 1,2-Ethanediol, Antifreeze, Caswell No. 441, EINECS 203-473-3, EPA Pesticide Chemical Code 042203 (+4 more)

CAS 107-21-1

Ethylene glycol (CAS 107-21-1) is a chemical substance with GHS signal word Warning; key hazard signal: H302. Key regulatory status: California Proposition 65, REACH registered, 32 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for GLYCOL →

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 15 fields

Name

Ethylene glycol

CAS Number

107-21-1

DTXSID

DTXSID8020597

Molecular Formula

C2H6O2

InChI Key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

Monoisotopic Mass

62.036779

Synonyms

1,2-EthanediolAntifreezeCaswell No. 441EINECS 203-473-3EPA Pesticide Chemical Code 042203Glycol, ethylene-NCI-C00920UNII-FC72KVT52FEthanediol

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	developmental	No	Yes	-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 4 *	H302	GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Harmful if swallowed May cause damage to kidneys and central nervous system
Short-term Effects	The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the kidneys, central nervous system and acid-base balance in the body. This may result in renal failure, brain injury and metabolic acidosis. Exposure could cause lowering of consciousness.
Routes of Exposure	The substance can be absorbed into the body by inhalation and through the skin.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 3 records

Agency	Metric	Value	ppm	mg/m3	Skin
ACGIH	TWA	25 ppm (vapor fraction) [2016]	25	-	N
ACGIH	STEL	50 ppm (vapor fraction), 10 mg/m³ (inhalable particulate matter, aerosol only) [2016]	50	10	N
CAL/OSHA	CEILING	40 ppm (100 mg/m³)	40	100	N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

SolventHumectantViscosity modifierFragranceThickening agentDemulsifierAnti-slip agentChemical reaction regulatorStabilizing agentDyeAdhesion/cohesion promoterSurfactant (surface active agent)Degradant/impurityProcessing aids not otherwise specifiedPlasticizerNo specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 32 records

List	Keyword	Source
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
fracking; water	NY Department of Conservation	CPCat
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
detected; general_crops; Pesticides; residue	FDA	United States Food and Drug Administration (FDA)
IFRA Transparency	IFRA	IFRA
children; WA Children's Safe Product Act (4/2020)	State of Washington Department of Ecology	State of Washington
fracking	FracFocus	FracFocus
children	Vermont Department of Health	State of Vermont
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
children	Oregon Health Authority	State of Oregon
OEHHA Proposition 65 (3/2019)	STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY	OEHHA Proposition 65 List
OEHHA Proposition 65 (1/2023)	California Office of Environmental Health Hazard Assessment	OEHHA Proposition 65 List
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe	Danish Environmental Protection Agency	Danish EPA
Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
=75.56	mg/kg bw/day	BMDL (10)	oral	Mouse	ToxValDB_ATSDR_MRLs
ABoral=8700	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
ABoral=8700	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
ABoral=8700	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
ABoral=8700	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
ABdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
=35	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
FC72KVT52F	UNII	FDA UNII substance identifier	-	-	openFDA substances
FC72KVT52F	UNII	FDA UNII substance identifier	-	-	openFDA substances
FC72KVT52F	UNII	FDA UNII substance identifier	-	-	openFDA substances
FC72KVT52F	UNII	FDA UNII substance identifier	-	-	openFDA substances
>2000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=4000	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
=4600	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
=4700	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=5380	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=5890	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=6133	mg/kg bw	LD50	oral	Rat (Male/Female)	NTP_ICE_acute_oral
>6690	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=7000	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
=7712	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=7887	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=8120	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=8540	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=9058	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
>10000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=10017	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=10020	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=10880	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=11300	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=13000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
<13380	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
<13400	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=16200	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=160	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=160	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=1250	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=1250	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=1500	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=3000	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=3750	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_ToxRefDB
=3750	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
>7500	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_ToxRefDB
>7500	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=81234.6	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=12	mg/m3	LOAEL	inhalation	Rat	ToxValDB_TX_TCEQ
=140	mg/m3	LOAEL	inhalation	Human	ToxValDB_TX_TCEQ

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Ethane-1,2-diol	203-473-3	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Ethylene glycol	-	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ETHYLENE GLYCOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Ethylene glycol?

Ethylene glycol (CAS 107-21-1) is classified under EU CLP Annex VI as Acute Tox. 4 * with signal word Warning. Hazard statements: H302. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Ethylene glycol?

Ethylene glycol has 100 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include Ethylene glycol?

Ethylene glycol appears on 19 regulatory/inventory lists including air; detected; emissions; Europe; Toys and children's products, fracking; water, active_ingredient; Europe; Pesticides, and 16 more. Source: EPA CPDat.

Is Ethylene glycol on the California Proposition 65 list?

Yes, Ethylene glycol is listed under California Proposition 65 for developmental. Source: California OEHHA Proposition 65.

What are the occupational exposure limits for Ethylene glycol?

Occupational exposure limits for Ethylene glycol are set by ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Ethylene glycol used in cosmetics?

Yes, Ethylene glycol is also indexed as a cosmetic ingredient under the name GLYCOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ethylene glycol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Ethylene glycol used outside industrial chemicals?

Ethylene glycol also appears in cosmetics, pharmaceutical, cannabis databases.