Also known as: 1.2-Ethylene dichloride, Ethane, 1,2-dichloro-, Brocide, Dichlor-Mulsion, Glycol dichloride (+15 more)
CAS 107-06-2
1,2-Dichloroethane (CAS 107-06-2) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H350; H302; H335; H315; H319. Key regulatory status: SVHC Candidate List, California Proposition 65, REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ECHA SVHC, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
1,2-Dichloroethane is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H350, H302, H335, H315, H319).
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 1998 | 20, Sup 7, 71 |
Candidate List status and reason under the ECHA REACH SVHC program.
| Substance | Reason | Included |
|---|---|---|
| 1,2-dichloroethane | Carcinogenic (Article 57a) | 19-Dec-2011 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; Carc. 1B; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2 | H225; H350; H302; H335; H315; H319 | GHS02; GHS08; GHS07 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour Harmful if swallowed May be harmful in contact with skin Toxic if inhaled Causes skin and eye irritation Suspected of causing cancer Causes damage to lungs, liver and kidneys May cause drowsiness or dizziness May cause damage to liver and kidneys through prolonged or repeated exposure Harmful to aquatic life |
| Short-term Effects | The vapour is irritating to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. See Notes. The substance may cause effects on the kidneys and liver. This may result in impaired functions, liver damage and kidney damage. Exposure at high concentrations could cause lowering of consciousness and death. The effects may be delayed. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the liver and kidneys, resulting in impaired functions. This substance is possibly carcinogenic to humans. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 50 ppm (200 mg/m³) | 50 | 200 | N |
| OSHA | CEILING | 100 ppm [5 min any 3 hrs]; 200 ppm (Peak) | 100 | - | N |
| NIOSH | TWA | 1 ppm (4 mg/m³) | 1 | 4 | N |
| NIOSH | STEL | 2 ppm (8 mg/m³) | 2 | 8 | N |
| ACGIH | TWA | 10 ppm [1977] | 10 | - | N |
| CAL/OSHA | TWA | 1 ppm (4 mg/m³) | 1 | 4 | N |
| CAL/OSHA | STEL | 2 ppm (8 mg/m³) | 2 | 8 | N |
| CAL/OSHA | CEILING | 200 ppm | 200 | - | N |
| NIOSH | IDLH | 50 ppm | 50 | - | - |
| AIHA | ERPG-1 | 50 ppm | 50 | - | - |
| AIHA | ERPG-2 | 200 ppm | 200 | - | - |
| AIHA | ERPG-3 | 300 ppm | 300 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| banned; Europe; Personal care | European Commission | CosIng |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| Pesticides | National Park Service | CPCat |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| Cons electronics mech appliances and machinery; Europe | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =232.382 | mg/m3 | BMCL (10) | inhalation | Rat | ToxValDB_ATSDR_MRLs |
| =37.1924 | mg/m3 | BMCL (HEC) | inhalation | Rat | ToxValDB_ATSDR_MRLs |
| SQE10 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE10 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE10 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE10 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 21.34 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 115.7 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| 55163IJI47 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 55163IJI47 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 55163IJI47 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 55163IJI47 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.3475 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| 0.6167 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 0.000026 | ug/m3 | Inhalation risk unit | Inhalation | - | NTP_ICE_cancer |
| 4.0445 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 5.1 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 7.758 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >8.089 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >670 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <890 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =18 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =30 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =40.4706 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_EPA_TSCA_8e |
| =47 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =47 | mg/kg bw/day | LEL | oral | rat | ToxRefDB_ToxRefDB_v3_pod.csv |
| =82 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =82 | mg/kg bw/day | LEL | oral | rat | ToxRefDB_ToxRefDB_v3_pod.csv |
| =86 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =86 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =88 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =88 | mg/kg bw/day | LEL | oral | rat | ToxRefDB_ToxRefDB_v3_pod.csv |
| =97 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =97 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =102 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =102 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =149 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =149 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =244 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =244 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =249 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =249 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
Showing 50 of 100 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,2-dichloroethane | 203-458-1 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| 1,2-Dichloroethane | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
1 food-safety record found.
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →1,2-Dichloroethane (CAS 107-06-2) is classified under EU CLP Annex VI as Flam. Liq. 2; Carc. 1B; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2 with signal word Danger. Hazard statements: H225; H350; H302; H335; H315; H319. Source: EU CLP Annex VI (ECHA).
1,2-Dichloroethane has 100 NOAEL studies in the database. The lowest reported value is 0 mg/kg bw/day via oral in rat. Source: ToxRefDB_ToxRefDB_v3_pod.csv.
1,2-Dichloroethane appears on 11 regulatory/inventory lists including detected; Europe; Other direct contact consumer goods, air; detected; emissions; Europe; Other direct contact consumer goods, detected; drinking_water; MN Chemical Screening, and 8 more. Source: EPA CPDat.
1,2-Dichloroethane is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, 1,2-Dichloroethane is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Yes, 1,2-Dichloroethane is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Carcinogenic (Article 57a). Source: ECHA SVHC Candidate List.
Occupational exposure limits for 1,2-Dichloroethane are set by OSHA, NIOSH, ACGIH. 12 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, 1,2-Dichloroethane is also indexed as a cosmetic ingredient under the name Ethylene Dichloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ECHA SVHC Candidate List, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
1,2-Dichloroethane is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H350, H302, H335, H315, H319).
1,2-Dichloroethane also appears in cosmetics, pharmaceutical, food safety, cannabis databases.