Danger GHS02GHS06GHS05GHS09 NOAEL Data IARC Group 2A REACH Registered Cosmetic Ingredient

Acrolein

Also known as: 2-Propenal, Caswell No. 009, EINECS 203-453-4, EPA Pesticide Chemical Code 000701, RCRA waste number P003 (+15 more)

CAS 107-02-8

Acrolein (CAS 107-02-8) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H330; H311; H300; H314; H400; H410. Key regulatory status: REACH registered, 31 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Acrolein →

Cross-Vertical Regulatory Divergence

Acrolein is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H330, H311, H300, H314, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Acrolein

CAS Number

107-02-8

DTXSID

DTXSID5020023

Molecular Formula

C3H4O

InChI Key

HGINCPLSRVDWNT-UHFFFAOYSA-N

Monoisotopic Mass

56.026215

Synonyms

2-PropenalCaswell No. 009EINECS 203-453-4EPA Pesticide Chemical Code 000701RCRA waste number P003AcraldehydeacroleinaAcroleineAkroleinAkroleinaAldehyde acryliqueAldeide acrilicaUNII-7864XYD3JJ

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 2A	Probably carcinogenic	2020	63, Sup 7, 128

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 2; Acute Tox. 1; Acute Tox. 3; Acute Tox. 2; Skin Corr. 1B; Aquatic Acute 1; Aquatic Chronic 1	H225; H330; H311; H300; H314; H400; H410	GHS02; GHS06; GHS05; GHS09	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Extremely flammable liquid and vapour Causes severe skin burns and eye damage Fatal if swallowed or in contact with skin Toxic if inhaled May cause cancer May cause damage to upper respiratory tract through prolonged or repeated exposure Very toxic to aquatic life
Short-term Effects	Lachrymation. The vapour is severely irritating to the respiratory tract. The substance is corrosive to the eyes and skin. Inhalation of high concentrations may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated.
Long-term Effects	The substance may have effects on the respiratory tract. This substance is probably carcinogenic to humans.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. Serious local effects by all routes of exposure.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 8 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	0.1 ppm (0.25 mg/m³)	0.1	0.25	N
NIOSH	TWA	0.1 ppm (0.25 mg/m³)	0.1	0.25	N
NIOSH	STEL	0.3 ppm (0.8 mg/m³)	0.3	0.8	N
CAL/OSHA	CEILING	0.1 ppm [0.25 mg/m³]	0.1	0.25	Y
NIOSH	IDLH	2 ppm	2	-	-
AIHA	ERPG-1	0.05 ppm	0.05	-	-
AIHA	ERPG-2	0.15 ppm	0.15	-	-
AIHA	ERPG-3	1.5 ppm	1.5	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

Flavouring and nutrientBiocideNo specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 31 records

List	Keyword	Source
air; emissions; Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
active_ingredient; agricultural; Pesticides	Arizona Department of Environmental Quality	State of Arizona
active_ingredient; agricultural; Pesticides	Arizona Department of Environmental Quality	State of Arizona
active_ingredient; agricultural; Pesticides	Arizona Department of Environmental Quality	State of Arizona
active_ingredient; agricultural; Pesticides	Arizona Department of Environmental Quality	State of Arizona
active_ingredient; agricultural; Pesticides	Arizona Department of Environmental Quality	State of Arizona
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Australia	Australian Pesticides and Veterinary Medicines Authority	CPCat
air; detected; emissions; Europe; Furniture and Furnishings	Danish Environmental Protection Agency	Danish EPA
air; emissions; Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; emissions; Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; emissions; Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; emissions; Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; emissions; Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - air freshener; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - air freshener; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - air freshener; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
air; detected; emissions; Europe; Road vehicles	Danish Environmental Protection Agency	Danish EPA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
air; emissions; Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; emissions; Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Europe	European Commission	Fl@vis

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 92 studies

Value	Unit	Endpoint	Route	Species	Source
=0.36	mg/kg bw/day	BMDL (10)	oral	Mouse	ToxValDB_ATSDR_MRLs
=0.2	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
7864XYD3JJ	UNII	FDA UNII substance identifier	-	-	openFDA substances
7864XYD3JJ	UNII	FDA UNII substance identifier	-	-	openFDA substances
7864XYD3JJ	UNII	FDA UNII substance identifier	-	-	openFDA substances
7864XYD3JJ	UNII	FDA UNII substance identifier	-	-	openFDA substances
2A	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2A	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2A	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	unitless	IARC group	-	-	NTP_ICE_cancer
0.017	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
0.018	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
0.0183	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
0.019	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
0.0202	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
0.055	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
0.0596	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
0.1375	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
0.3002	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=10	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=11	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
=26	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=29	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=42	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=46	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=2.75162	mg/m3	LEL	inhalation	Human	ToxValDB_NIOSH_IDLH
=4.12743	mg/m3	LEL	inhalation	Human	ToxValDB_NIOSH_IDLH
=4.58604	mg/m3	LEL	inhalation	Human	ToxValDB_NIOSH_IDLH
=12.6116	mg/m3	LEL	inhalation	Human	ToxValDB_NIOSH_IDLH
=64204.5	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=0.0275162	mg/m3	LOAEL	inhalation	Rat (Not Specified; M/F)	ATSDR_toxval_ATSDR_MRLs.xlsx
=0.13	mg/m3	LOAEL	-	Human	INCHEM_WHO_ehc_ehc_ehc127
=0.13	mg/m3	LOAEL	-	Human	INCHEM_WHO_ehc_ehc_ehc127
=0.137581	mg/m3	LOAEL	inhalation	Human	ToxValDB_Cal_OEHHA_REL_derivations
=0.206372	mg/m3	LOAEL	inhalation	Human	ToxValDB_EU_SCOEL
=0.22	ppm	LOAEL	-	Dog	INCHEM_WHO_cicads_cicads_cicad43
=0.458604	mg/m3	LOAEL	inhalation	Rat	ToxValDB_EU_SCOEL
=0.5	mg/m3	LOAEL	oral	Dog	INCHEM_WHO_cicads_cicads_cicad43
=0.687905	mg/m3	LOAEL	inhalation	Human	ToxValDB_ATSDR_MRLs
=0.687905	mg/m3	LOAEL	inhalation	Human (M/F)	ATSDR_toxval_ATSDR_MRLs.xlsx
=0.9	mg/m3	LOAEL	inhalation	Rat	ToxValDB_IRIS
=0.9	mg/m3	LOAEL	-	Rat	INCHEM_WHO_cicads_cicads_cicad43
=0.917207	mg/m3	LOAEL	inhalation	Rat	ToxValDB_ATSDR_MRLs
=0.917207	mg/m3	LOAEL	inhalation	Rat (Not Specified; M/F)	ATSDR_toxval_ATSDR_MRLs.xlsx
=1.37581	mg/m3	LOAEL	inhalation	Rat	ToxValDB_TX_TCEQ
=13	mg/m3	LOAEL	inhalation	Human	INCHEM_WHO_ehc_ehc_ehc127
=13	mg/m3	LOAEL	inhalation	Human	INCHEM_WHO_ehc_ehc_ehc127
=0.16	mg/m3	LOAEL (ADJ)	inhalation	Rat	ToxValDB_IRIS
=0.02	mg/m3	LOAEL (HEC)	inhalation	Rat	ToxValDB_IRIS
=0.02	mg/m^3	LOAEL (HEC)	inhalation	-	EPA_IRIS_iris_rfc_systems.csv

Showing 50 of 92 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Acrylaldehyde	203-453-4	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Acrolein	-	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ACROLEIN

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 7.5 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Acrolein?

Acrolein (CAS 107-02-8) is classified under EU CLP Annex VI as Flam. Liq. 2; Acute Tox. 1; Acute Tox. 3; Acute Tox. 2; Skin Corr. 1B; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H225; H330; H311; H300; H314; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Acrolein?

Acrolein has 92 NOAEL studies in the database. The lowest reported value is 0.00002 mg/m3 via inhalation in Human. Source: ToxValDB_IRIS.

What regulatory lists include Acrolein?

Acrolein appears on 11 regulatory/inventory lists including air; emissions; Europe; nondetect; Other direct contact consumer goods, active_ingredient; agricultural; Pesticides, active_ingredient; Pesticides, and 8 more. Source: EPA CPDat.

Is Acrolein a carcinogen according to IARC?

Acrolein is classified by IARC as Group 2A — probably carcinogenic to humans (evaluated 2020). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

What are the occupational exposure limits for Acrolein?

Occupational exposure limits for Acrolein are set by OSHA, NIOSH, CAL/OSHA. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Acrolein used in cosmetics?

Yes, Acrolein is also indexed as a cosmetic ingredient under the name Acrolein. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Acrolein come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Acrolein have different safety status in cosmetics vs industrial chemicals?

Acrolein is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H330, H311, H300, H314, H400, H410).

Is Acrolein used outside industrial chemicals?

Acrolein also appears in cosmetics, pharmaceutical, food safety, cannabis databases.