Cosmetic Ingredient

Poloxamer

Also known as: Polyoxyethylene-polyoxypropylene block copolymer, Oxirane, methyl-, polymer with oxirane, block, Propylene oxide ethylene oxide block polymer, Propylene oxide-ethylene oxide block copolymer, Propylene oxide-ethylene oxide blocker copolymer (+15 more)

CAS 106392-12-5

Poloxamer (CAS 106392-12-5) is a chemical substance. Key regulatory status: 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA CPDat, AICIS.

View cosmetic safety profile for Poloxamer 407 →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields

Name

Poloxamer

CAS Number

106392-12-5

DTXSID

DTXSID70872897

Synonyms

Polyoxyethylene-polyoxypropylene block copolymerOxirane, methyl-, polymer with oxirane, blockPropylene oxide ethylene oxide block polymerPropylene oxide-ethylene oxide block copolymerPropylene oxide-ethylene oxide blocker copolymerPolyethylene glycol-polypropylene glycol block copolymerPolyethylene oxide-polyypropylene oxide block copolymerPluronic PRE 1740Poloxamer 401Poloxamer 185Kolliphor P 407Lutrol 98

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
Canada; consumer_product; Substances in Products - Canada (4/2014)	Government of Canada	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Canada; Personal care; Substances in PCP - Canada (4/2014)	Government of Canada	CPCat
pharmaceutical	US International Trade Commission	CPCat
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

7.5%

Frequently Asked Questions

What regulatory lists include Poloxamer?

Poloxamer appears on 6 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; non_food_use; Pesticides, Canada; Personal care; Substances in PCP - Canada (4/2014), and 3 more. Source: EPA CPDat.

Is Poloxamer used in cosmetics?

Yes, Poloxamer is also indexed as a cosmetic ingredient under the name Poloxamer 407. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Poloxamer come from?

Safety data is sourced from EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is Poloxamer used outside industrial chemicals?

Poloxamer also appears in cosmetics databases.