What is the NOAEL for Butane?
Butane has 13 NOAEL studies in the database. The lowest reported value is 6LV4FOR43R UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Butane
Also known as: n-Butane, Butyl hydride, EINECS 203-448-7, Methylethylmethane, Butanen (+7 more)
CAS 106-97-8
Butane (CAS 106-97-8) is a chemical substance. Key regulatory status: REACH registered, 38 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Butane is classified GHS Danger (H220, H280, H336, H340, H350) in the chemicals database but is restricted in EU cosmetics at max <0.1%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
38
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Butane
CAS Number
106-97-8
DTXSID
DTXSID7024665
Molecular Formula
C4H10
InChI Key
IJDNQMDRQITEOD-UHFFFAOYSA-N
Monoisotopic Mass
58.07825
Synonyms
n-ButaneButyl hydrideEINECS 203-448-7MethylethylmethaneButanenUNII-6LV4FOR43RE 943aE-943aE943aR-600n-Butann-C4H10
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the central nervous system. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
3 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 800 ppm (1900 mg/m³) | 800 | 1900 | N |
| ACGIH | TWA | 1000 ppm [2012] | 1000 | - | N |
| CAL/OSHA | TWA | 800 ppm (1900 mg/m³) | 800 | 1900 | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Propellants, non-motive (blowing agents)
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
38 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - general arts and crafts supplies - flocking; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Furniture and Furnishings | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Furniture and Furnishings | Danish Environmental Protection Agency | Danish EPA |
| air; Construction and building materials; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - oven - oven cleaner; Europe | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Home maintenance - caulk/sealant | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| banned; Europe; Personal care | European Commission | CosIng |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; Pesticides | EPA | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 6LV4FOR43R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6LV4FOR43R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6LV4FOR43R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6LV4FOR43R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 658 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 660.4671 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 1355 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 1443 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =45168.2 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =21394 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =21395.4 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =21395.4 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_HPVIS |
| =21863.8 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_TX_TCEQ |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Butane | 203-448-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
<0.1%
Category
Rheology Modifier
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BUTANE
ChEMBL Phase
1
Adverse Events
32
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Butane?
Butane appears on 23 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, inert_ingredient; non_food_use; Pesticides, Arts and crafts/Office supplies - general arts and crafts supplies - flocking; Europe, and 20 more. Source: EPA CPDat.
What are the occupational exposure limits for Butane?
Occupational exposure limits for Butane are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Butane used in cosmetics?
Yes, Butane is also indexed as a cosmetic ingredient under the name Butane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Butane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does Butane have different safety status in cosmetics vs industrial chemicals?
Butane is classified GHS Danger (H220, H280, H336, H340, H350) in the chemicals database but is restricted in EU cosmetics at max <0.1%.
Is Butane used outside industrial chemicals?
Butane also appears in cosmetics, pharmaceutical, food safety databases.