Also known as: Epichlorhydrin, Oxirane, 2-(chloromethyl)-, 2-(Chloromethyl)oxirane, BRN 0079785, Caswell No. 424 (+15 more)
CAS 106-89-8
Epichlorohydrin (CAS 106-89-8) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H350; H331; H311; H301; H314; H317. Key regulatory status: California Proposition 65, REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
Epichlorohydrin is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H350, H331, H311, H301, H314, H317).
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2A | Probably carcinogenic | 1998 | 11, Sup 7, 71 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
| - | male | No | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; Carc. 1B; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Skin Corr. 1B; Skin Sens. 1 | H226; H350; H331; H311; H301; H314; H317 | GHS02; GHS08; GHS06; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Flammable liquid and vapour Toxic if swallowed, in contact with skin or if inhaled Causes severe skin burns and eye damage May cause an allergic skin reaction May cause genetic defects May cause cancer |
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. The effects may be delayed. Medical observation is indicated. See Notes. Inhalation of the vapour may cause asthma-like reactions. The substance may cause effects on the central nervous system, kidneys and liver. This may result in convulsions, kidney impairment and liver impairment. Exposure at high levels could cause death. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the kidneys, liver and lungs. This may result in impaired functions. May cause heritable genetic damage to human germ cells. This substance is probably carcinogenic to humans. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 5 ppm (19 mg/m³) | 5 | 19 | Y |
| CAL/OSHA | TWA | 0.05 ppm (0.19 mg/m³) | 0.05 | 0.19 | Y |
| NIOSH | IDLH | 75 ppm | 75 | - | - |
| AIHA | ERPG-1 | 5 ppm | 5 | - | - |
| AIHA | ERPG-2 | 20 ppm | 20 | - | - |
| AIHA | ERPG-3 | 100 ppm | 100 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| Europe; Food contact items; Toys and children's products | Danish EPA | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| Cons electronics mech appliances and machinery; Europe | Danish Environmental Protection Agency | Danish EPA |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| children | Maine Department of Environmental Protection | State of Maine |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| SQE9 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE9 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE9 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE9 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABmale | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABmale | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABmale | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABmale | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 08OOR508C0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 08OOR508C0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 08OOR508C0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 08OOR508C0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2A | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2A | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2A | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 0.0000012 | ug/m3 | Inhalation risk unit | Inhalation | - | NTP_ICE_cancer |
| 0.9454 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.96 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 1.3614 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 1.5543 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 1.8908 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 2.1934 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 2.2 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 2.2009 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 2.4 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 2.4014 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 2.8022 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 3 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 3.073 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 8.1874 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 8.9588 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 10.5812 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 13.6784 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =40 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =90 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =175 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =210 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =218 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =282 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =0.5 | mL/kg-day | LEL | dermal | Rat | ToxValDB_EPA_TSCA_8e |
| =12.5 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =96 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_EPA_TSCA_8e |
| =946.017 | mg/m3 | LEL | inhalation | Rat | ToxValDB_EPA_TSCA_8e |
| =8968.24 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_EPA_TSCA_8e |
| =31407.8 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_EPA_TSCA_8e |
Showing 50 of 82 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1-chloro-2,3-epoxypropane | 203-439-8 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Epichlorohydrin | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Epichlorohydrin (CAS 106-89-8) is classified under EU CLP Annex VI as Flam. Liq. 3; Carc. 1B; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Skin Corr. 1B; Skin Sens. 1 with signal word Danger. Hazard statements: H226; H350; H331; H311; H301; H314; H317. Source: EU CLP Annex VI (ECHA).
Epichlorohydrin has 82 NOAEL studies in the database. The lowest reported value is 0.001 mg/m3 via inhalation in Human. Source: ToxValDB_IRIS.
Epichlorohydrin appears on 8 regulatory/inventory lists including banned; Europe; Personal care, Europe; Food contact items; Toys and children's products, drinking_water; Europe; manufacturing; plastic_additive, and 5 more. Source: EPA CPDat.
Epichlorohydrin is classified by IARC as Group 2A — probably carcinogenic to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Epichlorohydrin is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Occupational exposure limits for Epichlorohydrin are set by OSHA, CAL/OSHA, NIOSH. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Epichlorohydrin is also indexed as a cosmetic ingredient under the name Epichlorohydrin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Epichlorohydrin is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H350, H331, H311, H301, H314, H317).
Epichlorohydrin also appears in cosmetics, pharmaceutical, cannabis databases.