Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

(2E)-3,7-Dimethyl-2,6-octadien-1-ol

Also known as: (2E)-3,7-dimethylocta-2,6-dien-1-ol, 2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)-, 2,6-Octadien-1-ol, 3,7-dimethyl-, (E)-, trans-Geraniol, trans-3,7-Dimethyl-2,6-octadien-1-ol (+14 more)

CAS 106-24-1

(2E)-3,7-Dimethyl-2,6-octadien-1-ol (CAS 106-24-1) is a chemical substance with GHS signal word Warning; key hazard signal: H317. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Geraniol →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

(2E)-3,7-Dimethyl-2,6-octadien-1-ol

CAS Number

106-24-1

DTXSID

DTXSID8026727

Molecular Formula

C10H18O

InChI Key

GLZPCOQZEFWAFX-JXMROGBWSA-N

Monoisotopic Mass

154.135765

Synonyms

(2E)-3,7-dimethylocta-2,6-dien-1-ol2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)-2,6-Octadien-1-ol, 3,7-dimethyl-, (E)-trans-Geranioltrans-3,7-Dimethyl-2,6-octadien-1-ol(E)-3,7-Dimethyl-2,6-octadienolGeraniol 60Geraniol 980Geraniol BJtrans-1-Hydroxy-3,7-dimethyl-2,6-octadiene2,6-Octadien-1-ol, 3,7-dimethyl-,2,6-Octadien-1-ol, 3,7-dimetil-, (2E) -

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Skin Sens. 1	H317	GHS07	Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

Fragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - air freshener; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - air freshener; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - air freshener; Europe	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Europe; Pesticides	European Commission	CPCat
Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - body hygiene - hand soap	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - specialized bath products - bath salts	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - general moisturizing - hand/body lotion	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; detected; Europe; Personal care - body hygiene - body wash; Personal care - body hygiene - hand soap; Personal care - fragrance; Personal care - hair styling and care - shampoo	Danish Environmental Protection Agency	Danish EPA
children; detected; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - make-up and related	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - make-up and related	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 85 studies

Value	Unit	Endpoint	Route	Species	Source
46.708	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
53.62	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
123.03	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
123.3	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
133.85	ug/mL	CV70	Dermal	-	NTP_ICE_skin_sensitization
139.2	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
140	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
0.3125	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
7.8	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
18.25	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
0.25	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
5	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
6	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
=11.8	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
-3.1	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
-	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
0.6	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
10	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
0.3	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
5	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
110	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
209.8	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
11.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
11.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
11.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
11.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
26	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
26	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
26	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
26	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
>2000	uM	EC3	Dermal	-	NTP_ICE_skin_sensitization
3	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
3	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
3	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
3	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
=3	Unitless	EPA classification	oral	Rat (Female)	NTP_ICE_acute_oral
3	unitless	EPA classification	Dermal	Rabbit	NTP_ICE_skin_irritation
4	unitless	EPA classification	Dermal	Rat	NTP_ICE_acute_dermal
L837108USY	UNII	FDA UNII substance identifier	-	-	openFDA substances
L837108USY	UNII	FDA UNII substance identifier	-	-	openFDA substances
L837108USY	UNII	FDA UNII substance identifier	-	-	openFDA substances
L837108USY	UNII	FDA UNII substance identifier	-	-	openFDA substances
4	unitless	GHS Classification	Inhalation	-	NTP_ICE_acute_inhalation
=4	Unitless	GHS classification	oral	Rat (Female)	NTP_ICE_acute_oral
5	unitless	GHS classification	Dermal	Rat	NTP_ICE_acute_dermal
722	uM	IC50	Dermal	-	NTP_ICE_skin_sensitization
875	uM	IC50	Dermal	-	NTP_ICE_skin_sensitization
2	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
2.05	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization

Showing 50 of 85 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Geraniol	203-377-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

10 ppm in leave-on products, 100 ppm in rinse-off products

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL GERANIOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for (2E)-3,7-Dimethyl-2,6-octadien-1-ol?

(2E)-3,7-Dimethyl-2,6-octadien-1-ol (CAS 106-24-1) is classified under EU CLP Annex VI as Skin Sens. 1 with signal word Warning. Hazard statements: H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for (2E)-3,7-Dimethyl-2,6-octadien-1-ol?

(2E)-3,7-Dimethyl-2,6-octadien-1-ol has 85 NOAEL studies in the database. The lowest reported value is -3.1 % via Dermal. Source: NTP_ICE_skin_sensitization.

What regulatory lists include (2E)-3,7-Dimethyl-2,6-octadien-1-ol?

(2E)-3,7-Dimethyl-2,6-octadien-1-ol appears on 25 regulatory/inventory lists including Europe; Personal care; restricted, Europe, air; Cleaning products and household care - air freshener; detected; emissions; Europe, and 22 more. Source: EPA CPDat.

Is (2E)-3,7-Dimethyl-2,6-octadien-1-ol used in cosmetics?

Yes, (2E)-3,7-Dimethyl-2,6-octadien-1-ol is also indexed as a cosmetic ingredient under the name Geraniol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for (2E)-3,7-Dimethyl-2,6-octadien-1-ol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is (2E)-3,7-Dimethyl-2,6-octadien-1-ol used outside industrial chemicals?

(2E)-3,7-Dimethyl-2,6-octadien-1-ol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.