Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

(2E)-3,7-Dimethyl-2,6-octadien-1-ol

Also known as: (2E)-3,7-dimethylocta-2,6-dien-1-ol, 2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)-, 2,6-Octadien-1-ol, 3,7-dimethyl-, (E)-, trans-Geraniol, trans-3,7-Dimethyl-2,6-octadien-1-ol (+14 more)

CAS 106-24-1

(2E)-3,7-Dimethyl-2,6-octadien-1-ol (CAS 106-24-1) is a chemical substance with GHS signal word Warning; key hazard signal: H317. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Geraniol →

SOURCE noael studies public
NOAEL studies
85
SOURCE chemical inventory jurisdictions
Regulatory lists
60
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
(2E)-3,7-Dimethyl-2,6-octadien-1-ol
CAS Number
106-24-1
DTXSID
DTXSID8026727
Molecular Formula
C10H18O
InChI Key
GLZPCOQZEFWAFX-JXMROGBWSA-N
Monoisotopic Mass
154.135765
Synonyms
(2E)-3,7-dimethylocta-2,6-dien-1-ol2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)-2,6-Octadien-1-ol, 3,7-dimethyl-, (E)-trans-Geranioltrans-3,7-Dimethyl-2,6-octadien-1-ol(E)-3,7-Dimethyl-2,6-octadienolGeraniol 60Geraniol 980Geraniol BJtrans-1-Hydroxy-3,7-dimethyl-2,6-octadiene2,6-Octadien-1-ol, 3,7-dimethyl-,2,6-Octadien-1-ol, 3,7-dimetil-, (2E) -

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Skin Sens. 1H317GHS07Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
Fragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
EuropeDanish Environmental Protection AgencyDanish EPA
air; Cleaning products and household care - air freshener; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - air freshener; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - air freshener; EuropeDanish Environmental Protection AgencyDanish EPA
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
active_ingredient; Europe; PesticidesEuropean CommissionCPCat
Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshenerDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - body hygiene - hand soapDanish Environmental Protection AgencyDanish EPA
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bath saltsDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; detected; Europe; Personal care - body hygiene - body wash; Personal care - body hygiene - hand soap; Personal care - fragrance; Personal care - hair styling and care - shampooDanish Environmental Protection AgencyDanish EPA
children; detected; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - make-up and relatedDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - make-up and relatedDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; EuropeDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 85 studies
ValueUnitEndpointRouteSpeciesSource
46.708ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
53.62ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
123.03ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
123.3ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
133.85ug/mLCV70Dermal-NTP_ICE_skin_sensitization
139.2ug/mLCV75Dermal-NTP_ICE_skin_sensitization
140ug/mLCV75Dermal-NTP_ICE_skin_sensitization
0.3125%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
7.8%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
18.25%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
0.25%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
5%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
6%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
=11.8mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
-3.1%Depletion CysDermal-NTP_ICE_skin_sensitization
-%Depletion CysDermal-NTP_ICE_skin_sensitization
0.6%Depletion LysDermal-NTP_ICE_skin_sensitization
10%Depletion LysDermal-NTP_ICE_skin_sensitization
0.3%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
5%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
110uMEC1.5Dermal-NTP_ICE_skin_sensitization
209.8uMEC1.5Dermal-NTP_ICE_skin_sensitization
11.4%EC3DermalMouseNTP_ICE_skin_sensitization
11.4%EC3DermalMouseNTP_ICE_skin_sensitization
11.4%EC3DermalMouseNTP_ICE_skin_sensitization
11.4%EC3DermalMouseNTP_ICE_skin_sensitization
26%EC3DermalMouseNTP_ICE_skin_sensitization
26%EC3DermalMouseNTP_ICE_skin_sensitization
26%EC3DermalMouseNTP_ICE_skin_sensitization
26%EC3DermalMouseNTP_ICE_skin_sensitization
>2000uMEC3Dermal-NTP_ICE_skin_sensitization
3unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
3unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
3unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
3unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
=3UnitlessEPA classificationoralRat (Female)NTP_ICE_acute_oral
3unitlessEPA classificationDermalRabbitNTP_ICE_skin_irritation
4unitlessEPA classificationDermalRatNTP_ICE_acute_dermal
L837108USYUNIIFDA UNII substance identifier--openFDA substances
L837108USYUNIIFDA UNII substance identifier--openFDA substances
L837108USYUNIIFDA UNII substance identifier--openFDA substances
L837108USYUNIIFDA UNII substance identifier--openFDA substances
4unitlessGHS ClassificationInhalation-NTP_ICE_acute_inhalation
=4UnitlessGHS classificationoralRat (Female)NTP_ICE_acute_oral
5unitlessGHS classificationDermalRatNTP_ICE_acute_dermal
722uMIC50Dermal-NTP_ICE_skin_sensitization
875uMIC50Dermal-NTP_ICE_skin_sensitization
2ratioImaxDermal-NTP_ICE_skin_sensitization
2.05ratioImaxDermal-NTP_ICE_skin_sensitization
-%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization

Showing 50 of 85 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredGeraniol203-377-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
10 ppm in leave-on products, 100 ppm in rinse-off products
Category
fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL GERANIOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
7
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for (2E)-3,7-Dimethyl-2,6-octadien-1-ol?

(2E)-3,7-Dimethyl-2,6-octadien-1-ol (CAS 106-24-1) is classified under EU CLP Annex VI as Skin Sens. 1 with signal word Warning. Hazard statements: H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for (2E)-3,7-Dimethyl-2,6-octadien-1-ol?

(2E)-3,7-Dimethyl-2,6-octadien-1-ol has 85 NOAEL studies in the database. The lowest reported value is -3.1 % via Dermal. Source: NTP_ICE_skin_sensitization.

What regulatory lists include (2E)-3,7-Dimethyl-2,6-octadien-1-ol?

(2E)-3,7-Dimethyl-2,6-octadien-1-ol appears on 25 regulatory/inventory lists including Europe; Personal care; restricted, Europe, air; Cleaning products and household care - air freshener; detected; emissions; Europe, and 22 more. Source: EPA CPDat.

Is (2E)-3,7-Dimethyl-2,6-octadien-1-ol used in cosmetics?

Yes, (2E)-3,7-Dimethyl-2,6-octadien-1-ol is also indexed as a cosmetic ingredient under the name Geraniol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for (2E)-3,7-Dimethyl-2,6-octadien-1-ol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is (2E)-3,7-Dimethyl-2,6-octadien-1-ol used outside industrial chemicals?

(2E)-3,7-Dimethyl-2,6-octadien-1-ol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.