What is the NOAEL for Propane, 1,1'-[ethylidenebis(oxy)]bis-?
Propane, 1,1'-[ethylidenebis(oxy)]bis- has 8 NOAEL studies in the database. The lowest reported value is 277L28816Q UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Propane, 1,1'-[ethylidenebis(oxy)]bis-
Also known as: Acetaldehyde dipropyl acetal, Acetaldehyde-di-n-propyl acetal, BRN 1697928, Dipropyl acetal, EINECS 203-335-2 (+2 more)
CAS 105-82-8
Propane, 1,1'-[ethylidenebis(oxy)]bis- (CAS 105-82-8) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Acetaldehyde Dipropyl Acetal →
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noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
13 fields
Name
Propane, 1,1'-[ethylidenebis(oxy)]bis-
CAS Number
105-82-8
DTXSID
DTXSID5059325
Molecular Formula
C8H18O2
InChI Key
MISTZQJSHHTDCF-UHFFFAOYSA-N
Monoisotopic Mass
146.13068
Synonyms
Acetaldehyde dipropyl acetalAcetaldehyde-di-n-propyl acetalBRN 1697928Dipropyl acetalEINECS 203-335-21,1'-(Ethylidenebis(oxy))bispropanen-Propyl acetal
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
3 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 277L28816Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 277L28816Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 277L28816Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 277L28816Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,1-dipropoxyethane | 203-335-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: Evaluation is not completed mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Propane, 1,1'-[ethylidenebis(oxy)]bis-?
Propane, 1,1'-[ethylidenebis(oxy)]bis- appears on 2 regulatory/inventory lists including Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Propane, 1,1'-[ethylidenebis(oxy)]bis- used in cosmetics?
Yes, Propane, 1,1'-[ethylidenebis(oxy)]bis- is also indexed as a cosmetic ingredient under the name Acetaldehyde Dipropyl Acetal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Propane, 1,1'-[ethylidenebis(oxy)]bis- come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Propane, 1,1'-[ethylidenebis(oxy)]bis- used outside industrial chemicals?
Propane, 1,1'-[ethylidenebis(oxy)]bis- also appears in cosmetics, food safety databases.