What is the NOAEL for 2,4-Dimethylphenol?
2,4-Dimethylphenol has 21 NOAEL studies in the database. The lowest reported value is 38 uL/min/10^6 cells in Rat. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,4-Dimethylphenol
Also known as: 2,4-Xylenol, 4-06-00-03126, Benzene, 2,4-dimethyl-1-hydroxy-, BRN 0636244, Bulk Lysol Brand Disinfectant (+9 more)
CAS 105-67-9
2,4-Dimethylphenol (CAS 105-67-9) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, EPA TRI.
Cross-Vertical Regulatory Divergence
2,4-Dimethylphenol is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H311, H314, H317, H318, H411, H303, H312).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
21
SOURCE
chemical inventory jurisdictions
Regulatory lists
12
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
2,4-Dimethylphenol
CAS Number
105-67-9
DTXSID
DTXSID2021864
Molecular Formula
C8H10O
InChI Key
KUFFULVDNCHOFZ-UHFFFAOYSA-N
Monoisotopic Mass
122.073165
Synonyms
2,4-Xylenol4-06-00-03126Benzene, 2,4-dimethyl-1-hydroxy-BRN 0636244Bulk Lysol Brand DisinfectantCaswell No. 907ADu Cor Concentrated Fly InsecticideEINECS 203-321-6EPA Pesticide Chemical Code 086804Gable-Tite Dark CreosoteGable-Tite Light CreosoteLysol Brand disinfectant
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the skin, respiratory tract and eyes. Corrosive on ingestion. Inhalation of the aerosol may cause lung oedema. See Notes. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, by ingestion and through the skin. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrientNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 38 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| 5OD803C081 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5OD803C081 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5OD803C081 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5OD803C081 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.228 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| =2300 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =250 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_IRIS |
| =540 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =50 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_HPVIS |
| =50 | mg/kg/day | NOAEL | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| =67 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =1000 | mM | NOEL | dermal | Mouse | ToxValDB_ECOTOX |
| =0.01 | mg/kg bw/day | RfD | dermal | Human | ToxValDB_Alaska_DEC |
| =0.01 | mg/kg bw/day | RfD | dermal | Human | ToxValDB_Alaska_DEC |
| =0.02 | mg/kg bw/day | RfD | oral | Human | ToxValDB_Alaska_DEC |
| =0.02 | mg/kg bw/day | RfD | oral | Human | ToxValDB_Alaska_DEC |
| =0.02 | mg/kg/day | RfD | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| =0.05 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,4-xylenol | 203-321-6 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| 2,4-Dimethylphenol | - | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL29878
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2,4-Dimethylphenol?
2,4-Dimethylphenol appears on 4 regulatory/inventory lists including Europe, IFRA Transparency, consumer_product, and 1 more. Source: EPA CPDat.
Is 2,4-Dimethylphenol used in cosmetics?
Yes, 2,4-Dimethylphenol is also indexed as a cosmetic ingredient under the name 2,4-Xylenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,4-Dimethylphenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,4-Dimethylphenol have different safety status in cosmetics vs industrial chemicals?
2,4-Dimethylphenol is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H311, H314, H317, H318, H411, H303, H312).
Is 2,4-Dimethylphenol used outside industrial chemicals?
2,4-Dimethylphenol also appears in cosmetics, pharmaceutical, cannabis databases.