What is the NOAEL for Diethyl carbonate?
Diethyl carbonate has 23 NOAEL studies in the database. The lowest reported value is 17.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diethyl carbonate
Also known as: Carbonic ether, EINECS 203-311-1, NCI-C60899, Diethylester kyseliny uhlicite, Diethylkarbonat (+1 more)
CAS 105-58-8
Diethyl carbonate (CAS 105-58-8) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
23
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Diethyl carbonate
CAS Number
105-58-8
DTXSID
DTXSID3025041
Molecular Formula
C5H10O3
InChI Key
OIFBSDVPJOWBCH-UHFFFAOYSA-N
Monoisotopic Mass
118.062994
Synonyms
Carbonic etherEINECS 203-311-1NCI-C60899Diethylester kyseliny uhliciteDiethylkarbonatUNII-3UA92692HG
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Flavouring and nutrientNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 23 of 23 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =17.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =69.792 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3UA92692HG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3UA92692HG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3UA92692HG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3UA92692HG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >1.268 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >1.83 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >17.75 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =252 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =19500 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =12.6 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =35.7 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=1593 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =18995 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =20971 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =10.7 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=130 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~140 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| >=214.3 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=956 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 23 of 23 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diethyl carbonate | 203-311-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1533495
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Diethyl carbonate?
Diethyl carbonate appears on 1 regulatory/inventory list including Europe. Source: EPA CPDat.
Is Diethyl carbonate used in cosmetics?
Yes, Diethyl carbonate is also indexed as a cosmetic ingredient under the name Diethyl Carbonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diethyl carbonate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Diethyl carbonate used outside industrial chemicals?
Diethyl carbonate also appears in cosmetics, pharmaceutical databases.