Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Methyl acetoacetate

Also known as: Butanoic acid, 3-oxo-, methyl ester, Acetoacetic methyl ester, EINECS 203-299-8, Methyl acetylacetonate, Methylacetoacetate (+2 more)

CAS 105-45-3

Methyl acetoacetate (CAS 105-45-3) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Methyl Acetoacetate →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields

Name

Methyl acetoacetate

CAS Number

105-45-3

DTXSID

DTXSID9026716

Molecular Formula

C5H8O3

InChI Key

WRQNANDWMGAFTP-UHFFFAOYSA-N

Monoisotopic Mass

116.047344

Synonyms

Butanoic acid, 3-oxo-, methyl esterAcetoacetic methyl esterEINECS 203-299-8Methyl acetylacetonateMethylacetoacetateMethylester kyseliny acetoctoveUNII-CW4I82QAX1

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Eye Irrit. 2	H319	GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes and respiratory tract. Exposure could cause lowering of consciousness.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 21 of 21 studies

Value	Unit	Endpoint	Route	Species	Source
=29.167	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
CW4I82QAX1	UNII	FDA UNII substance identifier	-	-	openFDA substances
CW4I82QAX1	UNII	FDA UNII substance identifier	-	-	openFDA substances
CW4I82QAX1	UNII	FDA UNII substance identifier	-	-	openFDA substances
CW4I82QAX1	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
5400	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
>2000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>2230	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=2580	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
>2920	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
<2980	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=3000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=3228	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=3370	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
<3900	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
>7290	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
>1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_HPVIS
=1000	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 21 of 21 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Methyl acetoacetate	203-299-8	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3186053

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Methyl acetoacetate?

Methyl acetoacetate (CAS 105-45-3) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Methyl acetoacetate?

Methyl acetoacetate has 21 NOAEL studies in the database. The lowest reported value is 29.167 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Methyl acetoacetate?

Methyl acetoacetate appears on 2 regulatory/inventory lists including IFRA Transparency, Europe. Source: EPA CPDat.

Is Methyl acetoacetate used in cosmetics?

Yes, Methyl acetoacetate is also indexed as a cosmetic ingredient under the name Methyl Acetoacetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Methyl acetoacetate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Methyl acetoacetate used outside industrial chemicals?

Methyl acetoacetate also appears in cosmetics, pharmaceutical, cannabis databases.