NOAEL Data REACH Registered Cosmetic Ingredient

HC Yellow no. 13

Also known as: UNII-0448DT2KKS, 4-(2-Hydroxyethylamino)-3-nitrobenzotrifluoride, Ethanol, 2-((2-nitro-4-(trifluoromethyl)phenyl)amino)-, Ethanol, 2-(alpha,alpha,alpha-trifluoro-2-nitro-p-toluidino)-, HC Yellow 13

CAS 10442-83-8

HC Yellow no. 13 (CAS 10442-83-8) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for HC Yellow No. 13 →

Cross-Vertical Regulatory Divergence

HC Yellow no. 13 is prohibited in EU cosmetics but has active industrial GHS classifications (H411).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 11 fields

Name

HC Yellow no. 13

CAS Number

10442-83-8

DTXSID

DTXSID10146483

Molecular Formula

C9H9F3N2O3

InChI Key

NJZCRXQWPNNJNB-UHFFFAOYSA-N

Monoisotopic Mass

250.056527

Synonyms

UNII-0448DT2KKS4-(2-Hydroxyethylamino)-3-nitrobenzotrifluorideEthanol, 2-((2-nitro-4-(trifluoromethyl)phenyl)amino)-Ethanol, 2-(alpha,alpha,alpha-trifluoro-2-nitro-p-toluidino)-HC Yellow 13

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 26 of 26 studies

Value	Unit	Endpoint	Route	Species	Source
0448DT2KKS	UNII	FDA UNII substance identifier	-	-	openFDA substances
0448DT2KKS	UNII	FDA UNII substance identifier	-	-	openFDA substances
0448DT2KKS	UNII	FDA UNII substance identifier	-	-	openFDA substances
0448DT2KKS	UNII	FDA UNII substance identifier	-	-	openFDA substances
10	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=2.5	%	NOAEL	dermal	rat	SCCNFP_vision_codex
=2.5	%	NOAEL	dermal	rat	SCCNFP_vision_codex
=2.5	%	NOAEL	dermal	rat	SCCNFP_vision_codex
=2.5	%	NOAEL	dermal	rat	SCCNFP_vision_codex
=30	mg/kg	NOAEL	dermal	rabbit	SCCNFP_vision_codex
=30	mg/kg	NOAEL	dermal	rabbit	SCCNFP_vision_codex
=30	mg/kg	NOAEL	dermal	rabbit	SCCNFP_vision_codex
=30	mg/kg	NOAEL	dermal	rabbit	SCCNFP_vision_codex
=90	mg/kg bw	NOAEL	-	-	SCCNFP_vision_codex
=90	mg/kg	NOAEL	oral	rat	SCCNFP_vision_codex
=90	mg/kg bw	NOAEL	-	-	SCCNFP_vision_codex
=90	mg/kg	NOAEL	oral	rat	SCCNFP_vision_codex
=90	mg/kg bw	NOAEL	-	-	SCCNFP_vision_codex
=90	mg/kg	NOAEL	oral	rat	SCCNFP_vision_codex
=90	mg/kg bw	NOAEL	-	-	SCCNFP_vision_codex
=90	mg/kg	NOAEL	oral	rat	SCCNFP_vision_codex
2.5	%	developmental toxicity	dermal	rat	UnifiedCodex:SCCNFP:beta.noael_studies
90	mg/kg	developmental toxicity	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
30	mg/kg	repeated dose toxicity	dermal	rabbit	UnifiedCodex:SCCNFP:beta.noael_studies
90	mg/kg bw	reproductive toxicity	-	-	UnifiedCodex:SCCNFP:beta.noael_studies
90	mg/kg bw	reproductive toxicity	-	-	UnifiedCodex:SCCNFP:beta.noael_studies

Showing 26 of 26 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-(2-nitro-4-trifluoromethylphenylamino)ethanol	443-760-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed_with_terms

Conditions

Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Frequently Asked Questions

What is the NOAEL for HC Yellow no. 13?

HC Yellow no. 13 has 26 NOAEL studies in the database. The lowest reported value is 0448DT2KKS UNII. Source: openFDA substances.

What regulatory lists include HC Yellow no. 13?

HC Yellow no. 13 appears on 2 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring. Source: EPA CPDat.

Is HC Yellow no. 13 used in cosmetics?

Yes, HC Yellow no. 13 is also indexed as a cosmetic ingredient under the name HC Yellow No. 13. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for HC Yellow no. 13 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does HC Yellow no. 13 have different safety status in cosmetics vs industrial chemicals?

HC Yellow no. 13 is prohibited in EU cosmetics but has active industrial GHS classifications (H411).

Is HC Yellow no. 13 used outside industrial chemicals?

HC Yellow no. 13 also appears in cosmetics databases.