? NOAEL Data REACH Registered Cosmetic Ingredient

Bisoctrizole

Also known as: UNII-8NT850T0YS

CAS 103597-45-1

Bisoctrizole (CAS 103597-45-1) is a chemical substance; key hazard signal: H413. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Methylene Bis Benzotriazolyl Tetramethylbutylphenol (Ti →

SOURCE noael studies public
NOAEL studies
58
SOURCE chemical inventory jurisdictions
Regulatory lists
6
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 7 fields
Name
Bisoctrizole
CAS Number
103597-45-1
DTXSID
DTXSID2046703
Molecular Formula
C41H50N6O2
InChI Key
FQUNFJULCYSSOP-UHFFFAOYSA-N
Monoisotopic Mass
658.399525
Synonyms
UNII-8NT850T0YS

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Aquatic Chronic 4H413?-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 19 records
UV stabilizerStabilizing agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records
ListKeywordSource
Europe; Personal careEuropean CommissionCosIng
Europe; plastic_additiveEuropean Chemicals AgencyEuropean Chemicals Agency (ECHA)
pharmaceuticalUS International Trade CommissionCPCat
Canada; pharmaceuticalDrugBankDrugBank
Europe; Personal careEuropean CommissionCosIng
CEDIFDAUnited States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 58 studies
ValueUnitEndpointRouteSpeciesSource
800mg/kg bw/d-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
800mg/kg bw-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/d-dermalpigUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/d-dermalpigUnifiedCodex:SCCS_SHADOW:beta.noael_studies
>1000mg/kg bw/d-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
>1000mg/kg bw/d-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
>1000mg/kg bw/d-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/d-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=21.16mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
=23.5mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
8NT850T0YSUNIIFDA UNII substance identifier--openFDA substances
8NT850T0YSUNIIFDA UNII substance identifier--openFDA substances
8NT850T0YSUNIIFDA UNII substance identifier--openFDA substances
8NT850T0YSUNIIFDA UNII substance identifier--openFDA substances
=0.0144mg/kg bw/dNOAELdermalratSCCS_vision_codex
=0.0144mg/kg bw/dNOAELdermalratSCCS_vision_codex
=0.0144mg/kg bw/dNOAELdermalratSCCS_vision_codex
=0.0144mg/kg bw/dNOAELdermalratSCCS_vision_codex
=10%NOAELdermalratSCCS_vision_codex
=10%NOAELdermalratSCCS_vision_codex
=10%NOAELdermalratSCCS_vision_codex
=10%NOAELdermalratSCCS_vision_codex
=59.2mg/kg bw/dNOAELdermalratSCCS_vision_codex
=59.2mg/kg bw/dNOAELdermalratSCCS_vision_codex
=59.2mg/kg bw/dNOAELdermalratSCCS_vision_codex
=59.2mg/kg bw/dNOAELdermalratSCCS_vision_codex
=800mg/kg bw/dNOAELdermalratSCCS_vision_codex
=800mg/kg bwNOAELdermalratSCCS_vision_codex
=800mg/kg bw/dNOAELdermalratSCCS_vision_codex
=800mg/kg bwNOAELdermalratSCCS_vision_codex
=800mg/kg bw/dNOAELdermalratSCCS_vision_codex
=800mg/kg bwNOAELdermalratSCCS_vision_codex
=800mg/kg bw/dNOAELdermalratSCCS_vision_codex
=800mg/kg bwNOAELdermalratSCCS_vision_codex
=1000mg/kg bw/dNOAELdermalpigSCCS_vision_codex
=1000mg/kg bw/dNOAELdermalpigSCCS_vision_codex
=1000mg/kg bw/dNOAELdermalpigSCCS_vision_codex
=1000mg/kg bw/dNOAELdermalpigSCCS_vision_codex
800mg/kg bwcarcinogenicitydermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
800mg/kg bwcarcinogenicitydermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.0144mg/kg bw/ddermal absorptiondermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
59.2mg/kg bw/ddermal absorptiondermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/ddevelopmental toxicityoralrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/ddevelopmental toxicityoralrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/dgenotoxicitydermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/dgenotoxicitydermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
>1000mg/kg bw/dgenotoxicitydermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
10%repeated dose toxicitydermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
10%repeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/dreproductive toxicityoral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 50 of 58 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)403-800-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1546/1525 June 2015safe with restrictions10% (dermally applied)Very low dermal absorption demonstrated; in vitro genotoxicity negative; no data on particle uptake/internalisation by cells; potential bioaccumulation in environment
SCCS/1443/1118 March 2013insufficient dataDermal application safe regarding systemic effects (existing non-nano opinion stands at 10%); nano form: no concentration limit established pending genotoxicity dataGenotoxicity data insufficient for nano form; systemic effects via dermal route considered no concern; subsequent genotoxicity studies (submitted 2014) showed no mutagenic/clastogenic potential

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL BISOCTRIZOLE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Bisoctrizole?

Bisoctrizole (CAS 103597-45-1) is classified under EU CLP Annex VI as Aquatic Chronic 4. Hazard statements: H413. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Bisoctrizole?

Bisoctrizole has 58 NOAEL studies in the database. The lowest reported value is 0.0144 mg/kg bw/d via dermal in rat. Source: SCCS_vision_codex.

What regulatory lists include Bisoctrizole?

Bisoctrizole appears on 5 regulatory/inventory lists including Europe; Personal care, Europe; plastic_additive, pharmaceutical, and 2 more. Source: EPA CPDat.

Is Bisoctrizole used in cosmetics?

Yes, Bisoctrizole is also indexed as a cosmetic ingredient under the name Methylene Bis Benzotriazolyl Tetramethylbutylphenol (Ti. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Bisoctrizole come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is Bisoctrizole used outside industrial chemicals?

Bisoctrizole also appears in cosmetics, pharmaceutical databases.