What is the NOAEL for Phenylacetic acid?
Phenylacetic acid has 13 NOAEL studies in the database. The lowest reported value is 16.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Phenylacetic acid
Also known as: 4-09-00-01614, Benzylcarboxylic acid, BRN 1099647, EINECS 203-148-6, FEMA No. 2878 (+15 more)
CAS 103-82-2
Phenylacetic acid (CAS 103-82-2) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Phenylacetic acid is classified GHS Danger (H318, H319) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Phenylacetic acid
CAS Number
103-82-2
DTXSID
DTXSID2021656
Molecular Formula
C8H8O2
InChI Key
WLJVXDMOQOGPHL-UHFFFAOYSA-N
Monoisotopic Mass
136.052429
Synonyms
4-09-00-01614Benzylcarboxylic acidBRN 1099647EINECS 203-148-6FEMA No. 2878Phenyllacetic acidKyselina fenyloctovaUNII-ER5I1W795A2-Phenylacetate2-Phenylethanoate2-Phenylethanoic acidBenzenacetic acid
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Causes mild skin irritation Causes eye irritation Harmful to aquatic life |
| Short-term Effects | The substance is irritating to the eyes. The substance is mildly irritating to the skin. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
FragranceNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| detected; Toys and children's products | Scientific Reports | Published Articles |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =16.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| ER5I1W795A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ER5I1W795A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ER5I1W795A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ER5I1W795A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1296 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =2250 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 45 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| 45 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 450 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Phenylacetic acid | 203-148-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PHENYLACETIC ACID
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
5
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Phenylacetic acid?
Phenylacetic acid appears on 7 regulatory/inventory lists including Australia; Food and drug - smoking-related products, detected; Toys and children's products, IFRA Transparency, and 4 more. Source: EPA CPDat.
Is Phenylacetic acid used in cosmetics?
Yes, Phenylacetic acid is also indexed as a cosmetic ingredient under the name Phenylacetic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Phenylacetic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Phenylacetic acid have different safety status in cosmetics vs industrial chemicals?
Phenylacetic acid is classified GHS Danger (H318, H319) in the chemicals database but is restricted in EU cosmetics.
Is Phenylacetic acid used outside industrial chemicals?
Phenylacetic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.