What is the NOAEL for 3-Phenylpropyl isobutyrate?
3-Phenylpropyl isobutyrate has 10 NOAEL studies in the database. The lowest reported value is Y9O48YFN18 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
3-Phenylpropyl isobutyrate
Also known as: Propanoic acid, 2-methyl-, 3-phenylpropyl ester, BRN 2454387, EINECS 203-125-0, FEMA No. 2893, Hydrocinnamyl isobutyrate (+6 more)
CAS 103-58-2
3-Phenylpropyl isobutyrate (CAS 103-58-2) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for Hydrocinnamyl Isobutyrate →
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
3-Phenylpropyl isobutyrate
CAS Number
103-58-2
DTXSID
DTXSID7059276
Molecular Formula
C13H18O2
InChI Key
VBTAKMZSMFMLGT-UHFFFAOYSA-N
Monoisotopic Mass
206.13068
Synonyms
Propanoic acid, 2-methyl-, 3-phenylpropyl esterBRN 2454387EINECS 203-125-0FEMA No. 2893Hydrocinnamyl isobutyrateHydrocinnamyl 2-methylpropanoateNSC 404455Phenylpropyl isobutyratePhenylpropyl 2-methylpropanoate, beta-3-Phenylpropyl 2-methylpropanoateUNII-Y9O48YFN18
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| Y9O48YFN18 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Y9O48YFN18 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Y9O48YFN18 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Y9O48YFN18 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 5400 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =275 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =275 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 3-Phenylpropyl isobutyrate?
3-Phenylpropyl isobutyrate appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 3-Phenylpropyl isobutyrate used in cosmetics?
Yes, 3-Phenylpropyl isobutyrate is also indexed as a cosmetic ingredient under the name Hydrocinnamyl Isobutyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3-Phenylpropyl isobutyrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 3-Phenylpropyl isobutyrate used outside industrial chemicals?
3-Phenylpropyl isobutyrate also appears in cosmetics, food safety, cannabis databases.