What is the NOAEL for Benzyl 3-methylbutanoate?
Benzyl 3-methylbutanoate has 8 NOAEL studies in the database. The lowest reported value is 87UKH01DMA UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Benzyl 3-methylbutanoate
Also known as: Butanoic acid, 3-methyl-, phenylmethyl ester, Benzyl isovalerate, Isovaleric acid, benzyl ester, Benzyl isopentanoate, Benzyl isovalerianate (+11 more)
CAS 103-38-8
Benzyl 3-methylbutanoate (CAS 103-38-8) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Benzyl 3-methylbutanoate
CAS Number
103-38-8
DTXSID
DTXSID1047603
Molecular Formula
C12H16O2
InChI Key
HVJKZICIMIWFCP-UHFFFAOYSA-N
Monoisotopic Mass
192.11503
Synonyms
Butanoic acid, 3-methyl-, phenylmethyl esterBenzyl isovalerateIsovaleric acid, benzyl esterBenzyl isopentanoateBenzyl isovalerianateBenzyl 3-methyl butyrateBenzyl 3-methylbutyrateBRN 2503435Butanoic acid, 3-methyl-, phenylethyl esterEINECS 203-106-7FEMA No. 2152Isopentanoic acid, phenylmethyl ester
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 87UKH01DMA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 87UKH01DMA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 87UKH01DMA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 87UKH01DMA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Benzyl isovalerate | 203-106-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3184059
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Benzyl 3-methylbutanoate?
Benzyl 3-methylbutanoate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Benzyl 3-methylbutanoate used in cosmetics?
Yes, Benzyl 3-methylbutanoate is also indexed as a cosmetic ingredient under the name Benzyl Isovalerate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Benzyl 3-methylbutanoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Benzyl 3-methylbutanoate used outside industrial chemicals?
Benzyl 3-methylbutanoate also appears in cosmetics, pharmaceutical, cannabis databases.