What is the NOAEL for Benzyl butyrate?
Benzyl butyrate has 10 NOAEL studies in the database. The lowest reported value is 27.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Benzyl butyrate
Also known as: Butanoic acid, phenylmethyl ester, Benzyl butanoate, Benzyl n-butanoate, Benzyl n-butyrate, BRN 2047625 (+7 more)
CAS 103-37-7
Benzyl butyrate (CAS 103-37-7) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Benzyl butyrate
CAS Number
103-37-7
DTXSID
DTXSID7047510
Molecular Formula
C11H14O2
InChI Key
VONGZNXBKCOUHB-UHFFFAOYSA-N
Monoisotopic Mass
178.09938
Synonyms
Butanoic acid, phenylmethyl esterBenzyl butanoateBenzyl n-butanoateBenzyl n-butyrateBRN 2047625EINECS 203-105-1FEMA No. 2140NSC 8073Phenylmethyl butanoatePhenylmethyl butyrateBenzylester kyseliny maselneUNII-84L0NDE31F
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
29 records
FragranceNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =27.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 84L0NDE31F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 84L0NDE31F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 84L0NDE31F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 84L0NDE31F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =2330 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 21 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Benzyl butyrate | 203-105-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3183179
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Benzyl butyrate?
Benzyl butyrate appears on 5 regulatory/inventory lists including Australia; Food and drug - smoking-related products, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.
Is Benzyl butyrate used in cosmetics?
Yes, Benzyl butyrate is also indexed as a cosmetic ingredient under the name Benzyl Butyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Benzyl butyrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Benzyl butyrate used outside industrial chemicals?
Benzyl butyrate also appears in cosmetics, pharmaceutical, cannabis databases.