What is the NOAEL for 2-Ethylhexyl acetate?
2-Ethylhexyl acetate has 13 NOAEL studies in the database. The lowest reported value is 17 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Ethylhexyl acetate
Also known as: Acetic acid, 2-ethylhexyl ester, 4-02-00-00166, Acetic acid alpha-ethylhexyl ester, BRN 1758321, EINECS 203-079-1 (+9 more)
CAS 103-09-3
2-Ethylhexyl acetate (CAS 103-09-3) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
2-Ethylhexyl acetate
CAS Number
103-09-3
DTXSID
DTXSID8026694
Molecular Formula
C10H20O2
InChI Key
WOYWLLHHWAMFCB-UHFFFAOYSA-N
Monoisotopic Mass
172.14633
Synonyms
Acetic acid, 2-ethylhexyl ester4-02-00-00166Acetic acid alpha-ethylhexyl esterBRN 1758321EINECS 203-079-12-Ethyl-1-hexanol acetatebeta-Ethylhexyl acetate2-Ethyl-1-hexyl acetateFEMA Number 2806NSC 88972-Ethylhexylester kyseliny octoveUNII-2C7K8OA8SB
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
SolventFragranceFlavouring and nutrientFilm former
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =71 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =17 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 2C7K8OA8SB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2C7K8OA8SB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2C7K8OA8SB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2C7K8OA8SB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =3000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =50 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-ethylhexyl acetate | 203-079-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1879713
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Ethylhexyl acetate?
2-Ethylhexyl acetate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, air; detected; emissions; Europe; Other direct contact consumer goods, and 1 more. Source: EPA CPDat.
Is 2-Ethylhexyl acetate used in cosmetics?
Yes, 2-Ethylhexyl acetate is also indexed as a cosmetic ingredient under the name Ethylhexyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Ethylhexyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Ethylhexyl acetate used outside industrial chemicals?
2-Ethylhexyl acetate also appears in cosmetics, pharmaceutical, cannabis databases.