NOAEL Data REACH Registered Cosmetic Ingredient

2-N-Dibutylaminoethanol

Also known as: 2-(Dibutylamino)ethanol, Ethanol, 2-(dibutylamino)-, 4-04-00-01506, BRN 1738441, Dibutylaminoethanol (+11 more)

CAS 102-81-8

2-N-Dibutylaminoethanol (CAS 102-81-8) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Dibutyl Ethanolamine →

Cross-Vertical Regulatory Divergence

2-N-Dibutylaminoethanol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H314, H318, H335, H227, H371, H373).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 22 fields

Name

2-N-Dibutylaminoethanol

CAS Number

102-81-8

DTXSID

DTXSID2024953

Molecular Formula

C10H23NO

InChI Key

IWSZDQRGNFLMJS-UHFFFAOYSA-N

Monoisotopic Mass

173.177964

Synonyms

2-(Dibutylamino)ethanolEthanol, 2-(dibutylamino)-4-04-00-01506BRN 1738441DibutylaminoethanolN,N-(Dibutylamino)ethanol2-Di-n-butylaminoethanolbeta-n-Dibutylaminoethyl alcoholDibutylethanolamineDi(n-butyl)ethanolamineN,N-DibutylethanolamineN,N-Dibutyl-N-(2-hydroxyethyl)amine

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is corrosive to the eyes and skin. The vapour is irritating to the respiratory tract. Corrosive on ingestion. The substance may cause effects on the central nervous system. This may result in convulsions and respiratory failure. Cholinesterase inhibition. Exposure could cause death. Medical observation is indicated. The effects may be delayed.
Routes of Exposure	The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 3 records

Agency	Metric	Value	ppm	mg/m3	Skin
NIOSH	TWA	2 ppm (14 mg/m³)	2	14	Y
ACGIH	TWA	0.5 ppm [1980]	0.5	-	Y
CAL/OSHA	TWA	2 ppm (14 mg/m³)	2	14	Y

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records

pH regulating agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 10 of 10 studies

Value	Unit	Endpoint	Route	Species	Source
=1.5	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
=2.22	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
3IT10X9MHO	UNII	FDA UNII substance identifier	-	-	openFDA substances
3IT10X9MHO	UNII	FDA UNII substance identifier	-	-	openFDA substances
3IT10X9MHO	UNII	FDA UNII substance identifier	-	-	openFDA substances
3IT10X9MHO	UNII	FDA UNII substance identifier	-	-	openFDA substances
=1070	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=200	mg/kg bw/day	LEL	oral	Rat	ToxValDB_EPA_TSCA_8e
=300	mg/kg bw/day	LEL	oral	Rat	ToxValDB_EPA_TSCA_8e
=100	mg/kg bw/day	NEL	oral	Rat	ToxValDB_EPA_TSCA_8e

Showing 10 of 10 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-dibutylaminoethanol	203-057-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1447214

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2-N-Dibutylaminoethanol?

2-N-Dibutylaminoethanol has 10 NOAEL studies in the database. The lowest reported value is 1.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 2-N-Dibutylaminoethanol?

2-N-Dibutylaminoethanol appears on 1 regulatory/inventory list including inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.

What are the occupational exposure limits for 2-N-Dibutylaminoethanol?

Occupational exposure limits for 2-N-Dibutylaminoethanol are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 2-N-Dibutylaminoethanol used in cosmetics?

Yes, 2-N-Dibutylaminoethanol is also indexed as a cosmetic ingredient under the name Dibutyl Ethanolamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-N-Dibutylaminoethanol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-N-Dibutylaminoethanol have different safety status in cosmetics vs industrial chemicals?

2-N-Dibutylaminoethanol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H314, H318, H335, H227, H371, H373).

Is 2-N-Dibutylaminoethanol used outside industrial chemicals?

2-N-Dibutylaminoethanol also appears in cosmetics, pharmaceutical databases.