What is the NOAEL for Triacetin?
Triacetin has 23 NOAEL studies in the database. The lowest reported value is 33.120960836374 uM. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Triacetin
Also known as: 1,2,3-Propanetriol triacetate, Glyceryl triacetate, 4-02-00-00253, BRN 1792353, EINECS 203-051-9 (+14 more)
CAS 102-76-1
Triacetin (CAS 102-76-1) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
23
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Triacetin
CAS Number
102-76-1
DTXSID
DTXSID3026691
Molecular Formula
C9H14O6
InChI Key
URAYPUMNDPQOKB-UHFFFAOYSA-N
Monoisotopic Mass
218.079038
Synonyms
1,2,3-Propanetriol triacetateGlyceryl triacetate4-02-00-00253BRN 1792353EINECS 203-051-9FEMA No. 2007FEMA Number 2007Kodaflex triacetinTriacetinumUNII-XHX3C3X6731,2,3-Propanetriyl triacetate1,2,3-triacetylglycerol
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is mildly irritating to the skin. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
SolventBiocideFilm formerPlasticizerDeodorizerFragranceHumectantPharmaceuticalFlavouring and nutrientProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 23 of 23 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 39.309013970844 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 33.120960836374 | uM | ACC | - | - | NTP_ICE_endocrine |
| 393 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =35.275 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| XHX3C3X673 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XHX3C3X673 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XHX3C3X673 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XHX3C3X673 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0000577 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 13500 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >1.721 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =89245.8 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =12200 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0182 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 1650 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =8000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 9500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =240 | mg/kg bw/day | NOAEL (HED) | oral | Rat | ToxValDB_PPRTV_(CPHEA) |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| =80 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 23 of 23 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Triacetin | 203-051-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Hair Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
TRIACETIN
ChEMBL Phase
2
Adverse Events
15
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E1518 — ADI: NOT SPECIFIED (1975) mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Triacetin?
Triacetin appears on 9 regulatory/inventory lists including IFRA Transparency, consumer_product, SCIL (9/2019), and 6 more. Source: EPA CPDat.
Is Triacetin used in cosmetics?
Yes, Triacetin is also indexed as a cosmetic ingredient under the name Triacetin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Triacetin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Triacetin used outside industrial chemicals?
Triacetin also appears in cosmetics, pharmaceutical, food safety databases.