What is the NOAEL for 2-Phenylethyl phenylacetate?
2-Phenylethyl phenylacetate has 13 NOAEL studies in the database. The lowest reported value is 0.628 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Phenylethyl phenylacetate
Also known as: Benzeneacetic acid, 2-phenylethyl ester, 3-09-00-02183, Benzylcarbinyl phenylacetate, Benzylcarbinyl alpha-toluate, BRN 2214383 (+9 more)
CAS 102-20-5
2-Phenylethyl phenylacetate (CAS 102-20-5) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
20 fields
Name
2-Phenylethyl phenylacetate
CAS Number
102-20-5
DTXSID
DTXSID0044494
Molecular Formula
C16H16O2
InChI Key
ZOZIRNMDEZKZHM-UHFFFAOYSA-N
Monoisotopic Mass
240.11503
Synonyms
Benzeneacetic acid, 2-phenylethyl ester3-09-00-02183Benzylcarbinyl phenylacetateBenzylcarbinyl alpha-toluateBRN 2214383EINECS 203-013-1FEMA No. 2866NSC 6676Phenethyl alpha-toluatePhenylacetic acid, phenethyl ester2-Phenylethyl benzeneacetatePhenylethyl phenylacetate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 57.48 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =0.628 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =4.9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 5J5OJ7GH15 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5J5OJ7GH15 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5J5OJ7GH15 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5J5OJ7GH15 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1296 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =15000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Phenethyl phenylacetate | 203-013-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3183441
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Phenylethyl phenylacetate?
2-Phenylethyl phenylacetate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is 2-Phenylethyl phenylacetate used in cosmetics?
Yes, 2-Phenylethyl phenylacetate is also indexed as a cosmetic ingredient under the name Phenethyl Phenylacetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Phenylethyl phenylacetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Phenylethyl phenylacetate used outside industrial chemicals?
2-Phenylethyl phenylacetate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.