What is the NOAEL for Diphenylmethane?
Diphenylmethane has 12 NOAEL studies in the database. The lowest reported value is 15.1816628236666 uM. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diphenylmethane
Also known as: AI3-28021-X, Benzene, benzyl-, EINECS 202-978-6, Toluene, alpha-phenyl-, UNII-K3E387I0BC (+5 more)
CAS 101-81-5
Diphenylmethane (CAS 101-81-5) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Diphenylmethane is prohibited in EU cosmetics but has active industrial GHS classifications (H400, H410).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Diphenylmethane
CAS Number
101-81-5
DTXSID
DTXSID1041891
Molecular Formula
C13H12
InChI Key
CZZYITDELCSZES-UHFFFAOYSA-N
Monoisotopic Mass
168.0939
Synonyms
AI3-28021-XBenzene, benzyl-EINECS 202-978-6Toluene, alpha-phenyl-UNII-K3E387I0BC(phenylmethyl)benzene1,1'-dimethylenebis(benzene)1,1'-methylenebisbenzenealpha-phenyltolueneditan
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
SolventDeodorizerDyeSurface modifierFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Europe; Other direct contact consumer goods; residue | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 16.4467606504509 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 15.1816628236666 | uM | ACC | - | - | NTP_ICE_endocrine |
| K3E387I0BC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K3E387I0BC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K3E387I0BC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K3E387I0BC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5184 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =2250 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0207 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diphenylmethane | 202-978-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DIPHENYLMETHANE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Diphenylmethane?
Diphenylmethane appears on 4 regulatory/inventory lists including Europe; Other direct contact consumer goods; residue, IFRA Transparency, Europe, and 1 more. Source: EPA CPDat.
Is Diphenylmethane used in cosmetics?
Yes, Diphenylmethane is also indexed as a cosmetic ingredient under the name Diphenyl Methane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diphenylmethane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Diphenylmethane have different safety status in cosmetics vs industrial chemicals?
Diphenylmethane is prohibited in EU cosmetics but has active industrial GHS classifications (H400, H410).
Is Diphenylmethane used outside industrial chemicals?
Diphenylmethane also appears in cosmetics, pharmaceutical, cannabis databases.