What is the NOAEL for 4,4'-Diphenylmethane diisocyanate?
4,4'-Diphenylmethane diisocyanate has 38 NOAEL studies in the database. The lowest reported value is 0.0256 mg/m3 via inhalation in Rat. Source: ToxValDB_Cal_OEHHA_REL_derivations.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
4,4'-Diphenylmethane diisocyanate
Also known as: 4,4'-Methylenedi(phenyl isocyanate), 1,1'-Methylenebis [4-isocyanatobenzene], 4,4'-MDI, 4-13-00-00396, BRN 0797662 (+15 more)
CAS 101-68-8
4,4'-Diphenylmethane diisocyanate (CAS 101-68-8) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
View cosmetic safety profile for Methylene Diphenyl Diisocyanate (MDI) →
Cross-Vertical Regulatory Divergence
4,4'-Diphenylmethane diisocyanate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H332, H334, H335, H351, H373).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
38
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
4,4'-Diphenylmethane diisocyanate
CAS Number
101-68-8
DTXSID
DTXSID7025180
Molecular Formula
C15H10N2O2
InChI Key
UPMLOUAZCHDJJD-UHFFFAOYSA-N
Monoisotopic Mass
250.074228
Synonyms
4,4'-Methylenedi(phenyl isocyanate)1,1'-Methylenebis [4-isocyanatobenzene]4,4'-MDI4-13-00-00396BRN 0797662Desmodur 44Di-(4-isocyanatophenyl)methane4,4'-DiphenylmethanediisocyanteEINECS 202-966-0Isocyanic acid, ester with diphenylmethaneIsonateIsonate 125M
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 19, Sup 7, 71 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | Lachrymation. The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the lungs. This may result in impaired functions. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
6 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | CEILING | 0.02 ppm (0.2 mg/m³) | 0.02 | 0.2 | N |
| NIOSH | TWA | 0.005 ppm (0.05 mg/m³) | 0.005 | 0.05 | N |
| NIOSH | CEILING | 0.020 ppm (0.2 mg/m³) [10 minutes] | 0.02 | 0.2 | N |
| ACGIH | TWA | 0.005 ppm [1985] | 0.005 | - | N |
| CAL/OSHA | TWA | 0.005 ppm (0.051 mg/m³) | 0.005 | 0.051 | N |
| NIOSH | IDLH | 75 mg/m³ | - | 75 | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
40 records
BinderHardenerAdhesion/cohesion promoterCatalystNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| Cons electronics mech appliances and machinery; Europe; nondetect | Danish EPA | Danish EPA |
| Europe; nondetect; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 38 of 38 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.25 | mg/m3 | BMC (05) | inhalation | Rat | ToxValDB_Cal_OEHHA_REL_derivations |
| =0.06 | mg/m3 | BMC (10 HEC) | inhalation | Rat | ToxValDB_IRIS |
| =0.14 | mg/m3 | BMC (10) | inhalation | Rat | ToxValDB_IRIS |
| =0.06 | mg/m^3 | BMC 10 (HEC) | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| =0.0256 | mg/m3 | BMCL (05) | inhalation | Rat | ToxValDB_Cal_OEHHA_REL_derivations |
| =0.05 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| B0LO6BBS8C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B0LO6BBS8C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B0LO6BBS8C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B0LO6BBS8C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 0.178 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.368 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.4155 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.4312 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.559 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >2.24 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =12 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =0.23 | mg/m | LOAEL | inhalation | Rat | ToxValDB_Cal_OEHHA_REL_derivations |
| =0.23 | mg/m3 | LOAEL | - | - | INCHEM_WHO_cicads_cicads_cicad27 |
| =0.98 | mg/m3 | LOAEL | - | - | INCHEM_WHO_cicads_cicads_cicad27 |
| =0.19 | mg/m3 | NOAEL | - | - | INCHEM_WHO_cicads_cicads_cicad27 |
| =2.2 | mg/m3 | NOAEL | - | - | INCHEM_WHO_cicads_cicads_cicad27 |
| =4 | mg/m3 | NOAEL | - | Rat | INCHEM_WHO_cicads_cicads_cicad27 |
| =8 | mg/m3 | NOAEL | inhalation | - | INCHEM_WHO_cicads_cicads_cicad27 |
| =9 | mg/m3 | NOAEL | - | - | INCHEM_WHO_cicads_cicads_cicad27 |
| =12 | mg/m3 | NOAEL | inhalation | - | INCHEM_WHO_cicads_cicads_cicad27 |
| =19 | mg/m3 | NOAEL | - | - | INCHEM_WHO_cicads_cicads_cicad27 |
| =98 | mg/m3 | NOAEL | - | - | INCHEM_WHO_cicads_cicads_cicad27 |
| =0.00002 | mg/m3 | RfC | inhalation | Human | ToxValDB_RSL |
| =0.0006 | mg/m3 | RfC | inhalation | Human | ToxValDB_IRIS |
| =0.0006 | mg/m^3 | RfC | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| <=0.0001 | mg/m3 | TDI | - | - | INCHEM_WHO_cicads_cicads_cicad27 |
| =0.05 | mg/m3 | TDI | - | Human | INCHEM_WHO_cicads_cicads_cicad27 |
| <=0.35 | mg/m3 | TDI | - | - | INCHEM_WHO_cicads_cicads_cicad27 |
Showing 38 of 38 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4,4'-methylenediphenyl diisocyanate | 202-966-0 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Diphenylmethane-4,4'-diisocyanate (MDI) | N120 - Diisocyanates | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1488467
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 4,4'-Diphenylmethane diisocyanate?
4,4'-Diphenylmethane diisocyanate appears on 6 regulatory/inventory lists including banned; Europe; Personal care, Cons electronics mech appliances and machinery; Europe; nondetect, Europe; nondetect; Toys and children's products, and 3 more. Source: EPA CPDat.
Is 4,4'-Diphenylmethane diisocyanate a carcinogen according to IARC?
4,4'-Diphenylmethane diisocyanate is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
What are the occupational exposure limits for 4,4'-Diphenylmethane diisocyanate?
Occupational exposure limits for 4,4'-Diphenylmethane diisocyanate are set by OSHA, NIOSH, ACGIH. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is 4,4'-Diphenylmethane diisocyanate used in cosmetics?
Yes, 4,4'-Diphenylmethane diisocyanate is also indexed as a cosmetic ingredient under the name Methylene Diphenyl Diisocyanate (MDI). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4,4'-Diphenylmethane diisocyanate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 4,4'-Diphenylmethane diisocyanate have different safety status in cosmetics vs industrial chemicals?
4,4'-Diphenylmethane diisocyanate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H332, H334, H335, H351, H373).
Is 4,4'-Diphenylmethane diisocyanate used outside industrial chemicals?
4,4'-Diphenylmethane diisocyanate also appears in cosmetics, pharmaceutical databases.