Also known as: Alcide, Chlorine dioxide (OClO), Clidox, Clidox-S, Diklor (+15 more)
CAS 10049-04-4
Chlorine dioxide (CAS 10049-04-4) is a chemical substance with GHS signal word Danger; key hazard signal: H270; H330; H314; H400. Key regulatory status: REACH registered, 38 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
Chlorine dioxide is classified GHS Danger (H270, H330, H314, H400, H301) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Ox. Gas 1; Press. Gas; Acute Tox. 2 *; Skin Corr. 1B; Aquatic Acute 1 | H270; H330; H314; H400 | GHS03; GHS04; GHS06; GHS05; GHS09 | Danger |
| Acute Tox. 3 *; Skin Corr. 1B; Aquatic Acute 1 | H301; H314; H400 | GHS06; GHS05; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is severely irritating to the eyes, skin and respiratory tract. Inhalation of this gas may cause lung oedema. See Notes. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated. |
| Long-term Effects | The substance may have effects on the lungs. This may result in chronic bronchitis. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 0.1 ppm (0.3 mg/m³) | 0.1 | 0.3 | N |
| NIOSH | TWA | 0.1 ppm (0.3 mg/m³) | 0.1 | 0.3 | N |
| NIOSH | STEL | 0.3 ppm (0.9 mg/m³) | 0.3 | 0.9 | N |
| CAL/OSHA | TWA | 0.1 ppm (0.3 mg/m³) | 0.1 | 0.3 | N |
| CAL/OSHA | STEL | 0.3 ppm (0.9 mg/m³) | 0.3 | 0.9 | N |
| NIOSH | IDLH | 5 mg/m³ | - | 5 | - |
| AIHA | ERPG-1 | -- | - | - | - |
| AIHA | ERPG-2 | 0.5 ppm | 0.5 | - | - |
| AIHA | ERPG-3 | 3 ppm | 3 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| - | Journal of Chemical Engineering & Process Technology | Published Articles |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| fracking; water | NY Department of Conservation | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.304 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =0.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 2 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 4 | unitless | EPA Classification | Inhalation | - | NTP_ICE_acute_inhalation |
| 2 | unitless | EPA classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| 4 | unitless | EPA classification | Dermal | Rat | NTP_ICE_acute_dermal |
| =4 | Unitless | EPA classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| 8061YMS4RM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8061YMS4RM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8061YMS4RM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8061YMS4RM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 1 | unitless | GHS Classification | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 1 | unitless | GHS Classification | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 1 | unitless | GHS Classification | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 5 | unitless | GHS Classification | Inhalation | - | NTP_ICE_acute_inhalation |
| 5 | unitless | GHS classification | Dermal | Rat | NTP_ICE_acute_dermal |
| =5 | Unitless | GHS classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| 0.04 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.041 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.048 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.089 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >5.06 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >5000 | mg/kg | LD50 | Dermal | Rat | NTP_ICE_acute_dermal |
| >5000 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =6.9 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =28 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =77.2437 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =0.827612 | mg/m3 | LOAEL | inhalation | Rat (Wistar; unknown) | ATSDR_toxval_ATSDR_MRLs.xlsx |
| =2.7587 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_ATSDR_MRLs |
| =2.7587 | mg/m3 | LOAEL | inhalation | Rat (Wistar; unknown) | ATSDR_toxval_ATSDR_MRLs.xlsx |
| =2.76 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_IRIS |
| =2.8 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =6 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_IRIS |
| =6.9 | mg/m3 | LOAEL | inhalation | Rabbit | ToxValDB_IRIS |
| >10 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =14 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =0.41 | mg/m3 | LOAEL (ADJ) | inhalation | Rat | ToxValDB_IRIS |
| =0.82 | mg/m3 | LOAEL (ADJ) | inhalation | Rabbit | ToxValDB_IRIS |
| =0.49 | mg/m3 | LOAEL (HEC) | inhalation | Rabbit | ToxValDB_IRIS |
| =0.64 | mg/m3 | LOAEL (HEC) | inhalation | Rat | ToxValDB_IRIS |
| =0.64 | mg/m^3 | LOAEL (HEC) | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| =0.827612 | mg/m3 | LOAEL (HEC) | inhalation | Rat | ToxValDB_ATSDR_MRLs |
| =0.00275871 | mg/m3 | MRL | inhalation | Human | ToxValDB_ATSDR_MRLs |
| =0.00275871 | mg/m3 | MRL | inhalation | Human | ToxValDB_ATSDR_MRLs |
| =14 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| 0.1 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 0.5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =1 | ppm | NOAEL | inhalation | Rat | INCHEM_WHO_cicads_cicads_cicad37 |
| 1.9 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 50 of 74 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Chlorine dioxide | 233-162-8 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Chlorine dioxide | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS food additive, ADI, and GRAS records where available.
1 food-safety record found.
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Chlorine dioxide (CAS 10049-04-4) is classified under EU CLP Annex VI as Ox. Gas 1; Press. Gas; Acute Tox. 2 *; Skin Corr. 1B; Aquatic Acute 1 with signal word Danger. Hazard statements: H270; H330; H314; H400. Source: EU CLP Annex VI (ECHA).
Chlorine dioxide has 74 NOAEL studies in the database. The lowest reported value is 0.04 mg/L via Inhalation. Source: NTP_ICE_acute_inhalation.
Chlorine dioxide appears on 7 regulatory/inventory lists including active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, inert_ingredient; non_food_use; Pesticides, and 4 more. Source: EPA CPDat.
Occupational exposure limits for Chlorine dioxide are set by OSHA, NIOSH, CAL/OSHA. 9 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Chlorine dioxide is also indexed as a cosmetic ingredient under the name Chlorine Dioxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Chlorine dioxide is classified GHS Danger (H270, H330, H314, H400, H301) in the chemicals database but is allowed in EU cosmetics.
Chlorine dioxide also appears in cosmetics, food safety, cannabis databases.