Also known as: Nitrogen oxide (N2O), EINECS 233-032-0, FEMA No. 2779, Nitrogen hypoxide, Nitrous oxide, compressed (+15 more)
CAS 10024-97-2
Nitrous oxide (CAS 10024-97-2) is a chemical substance with GHS signal word Danger; key hazard signal: H360Df; H336; H372 (nervous system); H420. Key regulatory status: California Proposition 65, REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, CA Prop 65, ILO ICSC, OSHA.
Nitrous oxide is classified GHS Danger (H360Df, H336, H372, H420) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | developmental, female | No | Yes | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Repr. 1B; STOT SE 3; STOT RE 1; Ozone 1 | H360Df; H336; H372 (nervous system); H420 | GHS08; GHS07 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | May cause or intensify fire; oxidizer Contains gas under pressure; may explode if heated May cause drowsiness or dizziness May damage fertility or the unborn child Causes damage to the blood and the nervous system through prolonged or repeated exposure if inhaled |
| Short-term Effects | The liquid may cause frostbite. The substance may cause effects on the central nervous system. This may result in lowering of consciousness. |
| Long-term Effects | The substance may have effects on the bone marrow and nervous system. May cause reproductive toxicity in humans. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 25 ppm (46 mg/m³) [waste anesthetic gases only] | 25 | 46 | N |
| ACGIH | TWA | 50 ppm [1986] | 50 | - | N |
| CAL/OSHA | TWA | 50 ppm (90 mg/m³) | 50 | 90 | N |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| ABdevelopmental, female | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABdevelopmental, female | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABdevelopmental, female | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABdevelopmental, female | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| =180 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =183 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| K50XQU1029 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K50XQU1029 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K50XQU1029 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K50XQU1029 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =900.066 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =18001.3 | mg/m3 | LOEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =360026 | mg/m3 | LOEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =1440110 | mg/m3 | LOEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| ~1800.13 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| <9000.66 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =18001.3 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| ~90006.6 | mg/m3 | NOAEC | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =180013 | mg/m3 | NOAEC | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =720053 | mg/m3 | NOAEC | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| >1260090 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
Showing 21 of 21 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dinitrogen oxide | 233-032-0 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Nitrous oxide (CAS 10024-97-2) is classified under EU CLP Annex VI as Repr. 1B; STOT SE 3; STOT RE 1; Ozone 1 with signal word Danger. Hazard statements: H360Df; H336; H372 (nervous system); H420. Source: EU CLP Annex VI (ECHA).
Nitrous oxide has 21 NOAEL studies in the database. The lowest reported value is developmental, female listing type. Source: California Proposition 65.
Nitrous oxide appears on 5 regulatory/inventory lists including OEHHA Proposition 65 (3/2019), food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Canada; pharmaceutical, and 2 more. Source: EPA CPDat.
Yes, Nitrous oxide is listed under California Proposition 65 for developmental, female. Source: California OEHHA Proposition 65.
Occupational exposure limits for Nitrous oxide are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Nitrous oxide is also indexed as a cosmetic ingredient under the name NITROUS OXIDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Nitrous oxide is classified GHS Danger (H360Df, H336, H372, H420) in the chemicals database but is allowed in EU cosmetics.
Nitrous oxide also appears in cosmetics, pharmaceutical databases.