What is the GHS hazard classification for Benzonitrile?
Benzonitrile (CAS 100-47-0) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 * with signal word Warning. Hazard statements: H312; H302. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Benzonitrile
Also known as: EINECS 202-855-7, Phenylcyanide, Fenylkyanid, UNII-9V9APP5H5S, C6H5-CN
CAS 100-47-0
Benzonitrile (CAS 100-47-0) is a chemical substance with GHS signal word Warning; key hazard signal: H312; H302. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
9
SOURCE
Chemical inventory jurisdictions
Regulatory lists
5
SOURCE
EU CLP Annex VI
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Benzonitrile
CAS Number
100-47-0
DTXSID
DTXSID7021491
Molecular Formula
C7H5N
InChI Key
JFDZBHWFFUWGJE-UHFFFAOYSA-N
Monoisotopic Mass
103.042199
Synonyms
EINECS 202-855-7PhenylcyanideFenylkyanidUNII-9V9APP5H5SC6H5-CN
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Acute Tox. 4 * | H312; H302 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the cellular respiration. This may result in cyanosis. The effects may be delayed. Medical observation is indicated. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 9V9APP5H5S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9V9APP5H5S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9V9APP5H5S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9V9APP5H5S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1350 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 3.9159 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =7971.59 | mg/m3 | LEL | inhalation | Mouse | ToxValDB NIOSH IDLH |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Benzonitrile | 202-855-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
BENZONITRILE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What is the NOAEL for Benzonitrile?
Benzonitrile has 9 NOAEL studies in the database. The lowest reported value is 9V9APP5H5S UNII. Source: openFDA substances.
What regulatory lists include Benzonitrile?
Benzonitrile appears on 5 regulatory/inventory lists including Cleaning products and household care - air freshener; Europe, air; Cleaning products and household care - air freshener; detected; emissions; Europe, IFRA Transparency, and 2 more. Source: EPA CPDat.
Is Benzonitrile used in cosmetics?
Yes, Benzonitrile is also indexed as a cosmetic ingredient under the name Benzonitrile. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Benzonitrile come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Benzonitrile used outside industrial chemicals?
Benzonitrile also appears in cosmetics, pharmaceutical databases.