EFSA toxicology reference values
Diacetyl
Diacetyl (CAS 431-03-8). Cannabis testing data across 0 states. Action levels when present, testing requirements, compliance status.
Diacetyl is a cannabis analyte contaminant represented in the cannabis public dataset.
Substance Identity
Analyte identity and classification used for this cannabis substance page.
Contaminant Class Badge
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Dataset Snapshot
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EFSA Substance Identity
EFSA substance identity rows matched by chemical name or CAS.
EFSA Reference Values
Reference values from efsa_reference_values_v2 for toxicology and food-safety context.
| Descriptor | Value | Population | Endpoint | Body |
|---|---|---|---|---|
| MSI/FC | 0.5 mg/day | cat | aa62a944-2d02-4338-96ae-5f7d86063e2b | - |
| MSI/FC | 1.8 mg/day | laying hen | aa62a944-2d02-4338-96ae-5f7d86063e2b | - |
| MSI/FC | 1.8 mg/day | salmon | aa62a944-2d02-4338-96ae-5f7d86063e2b | - |
| MSI/FC | 1.8 mg/day | chicken for fattening | aa62a944-2d02-4338-96ae-5f7d86063e2b | - |
| MSI/FC | 10.8 mg/day | turkey for fattening | aa62a944-2d02-4338-96ae-5f7d86063e2b | - |
| MSI/FC | 13.5 mg/day | dog | aa62a944-2d02-4338-96ae-5f7d86063e2b | - |
| MSI/FC | 18 mg/day | other: | aa62a944-2d02-4338-96ae-5f7d86063e2b | - |
| MSI/FC | 90 mg/day | cattle for fattening | aa62a944-2d02-4338-96ae-5f7d86063e2b | - |
| MSI/FC | 90 mg/day | other: | aa62a944-2d02-4338-96ae-5f7d86063e2b | - |
| MSI/FC | 180 mg/day | other: | aa62a944-2d02-4338-96ae-5f7d86063e2b | - |
| MSI/FC | 360 mg/day | cattle for fattening | aa62a944-2d02-4338-96ae-5f7d86063e2b | - |
| MSI/FC | 585 mg/day | dairy cow | aa62a944-2d02-4338-96ae-5f7d86063e2b | - |
EFSA Study Results
Endpoint-level study rows from efsa_study_results matched to this substance.
| Endpoint | Species | Route | Effect | Assessment |
|---|---|---|---|---|
| sub-chronic toxicity: oral | rat | oral: gavage | 90 other: | - |
| Carcinogenicity_EU_PPP | - | - | - | Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 11 compounds belonging to chemical group 10. They are currently authorised as flavours in food. |
| Carcinogenicity_EU_PPP | - | - | - | The European Food Safety Authority (EFSA) was asked by the European Commission, in accordance with Article 31 of Regulation (EC) No 178/2002, to assess a recent publication on the possible effect of diacetyl [FL-No 07.052] in enhancing -amyloid-induced neurotoxicity, and to verify whether these additional data are of concern for the safe use of diacetyl as a flavouring substance in food. In the scientific paper the authors conclude that industry workers exposed chronically via inhalation to diacetyl could possibly develop neurological symptoms related to diacetyl exposure. EFSA has evaluated the paper in relation to the potential risk of the use of diacetyl [FL-No 07.052] as flavouring agent in food. EFSA's evaluation concluded that the cytotoxicity assay and the cellular system used by the authors have shortcomings that did not allow the extrapolation of the data to be used in the safe assessment of diacetyl as a flavouring agent in food. Additionally, the authors have not provided any correlation between occupational exposure and systemic exposure. Based on these considerations, EFSA concluded that the information in scientific paper does not bring any new scientific elements for the safe use of diacetyl in food. |
| Genetic Toxicity | - | - | - | The European Food Safety Authority (EFSA) was asked by the European Commission, in accordance with Article 31 of Regulation (EC) No 178/2002, to assess a recent publication on the possible effect of diacetyl [FL-No 07.052] in enhancing -amyloid-induced neurotoxicity, and to verify whether these additional data are of concern for the safe use of diacetyl as a flavouring substance in food. In the scientific paper the authors conclude that industry workers exposed chronically via inhalation to diacetyl could possibly develop neurological symptoms related to diacetyl exposure. EFSA has evaluated the paper in relation to the potential risk of the use of diacetyl [FL-No 07.052] as flavouring agent in food. EFSA's evaluation concluded that the cytotoxicity assay and the cellular system used by the authors have shortcomings that did not allow the extrapolation of the data to be used in the safe assessment of diacetyl as a flavouring agent in food. Additionally, the authors have not provided any correlation between occupational exposure and systemic exposure. Based on these considerations, EFSA concluded that the information in scientific paper does not bring any new scientific elements for the safe use of diacetyl in food. |
| Genetic Toxicity | - | - | - | Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 11 compounds belonging to chemical group 10. They are currently authorised as flavours in food. |
Cross-Reference to Chemicals / Cosmetics / Food
Internal cross-vertical links connecting cannabis rows to chemical, cosmetics, and EFSA food/toxicology context.
Frequently Asked Questions
FAQ answers are generated from the same fetched cannabis, EFSA, cosmetics, and chemical rows rendered above.
What is the regulatory limit for Diacetyl in cannabis?
Diacetyl does not have a numeric cannabis_contaminant_tests range in the fetched page data. The current page query does not expose a separate action-limit column.
Which states test for Diacetyl?
Diacetyl does not have state-level cannabis testing rows in the fetched page data.
What are the EFSA reference values for Diacetyl?
Diacetyl has 13 EFSA OpenFoodTox reference value rows in the cannabis database, including MSI/FC, margin of safety.
Is Diacetyl also regulated in cosmetics or food?
Diacetyl has a cosmetics ingredient cross-reference with EU status prohibited. EFSA food/toxicology context is available on this page.