EFSA toxicology reference values
Spilanthol
Spilanthol (CAS 25394-57-4). Cannabis testing data across 0 states. Action levels when present, testing requirements, compliance status.
Spilanthol is a cannabis analyte contaminant represented in the cannabis public dataset.
Substance Identity
Analyte identity and classification used for this cannabis substance page.
Contaminant Class Badge
Color-coded cannabis class signal for scanning pesticide, metal, solvent, mycotoxin, and potency pages.
Dataset Snapshot
Compact public-data summary for page quality, state coverage, lab rows, and potency sample groups.
EFSA Substance Identity
EFSA substance identity rows matched by chemical name or CAS.
EFSA Reference Values
Reference values from efsa_reference_values_v2 for toxicology and food-safety context.
| Descriptor | Value | Population | Endpoint | Body |
|---|---|---|---|---|
| TTC Cramer Class III | 1.5 µg/kg bw/day | consumers | - | - |
| TTC Cramer Class III | 1.5 µg/kg bw/day | consumers | - | - |
| margin of safety | 59,000 other: | consumers | 662fa2e1-e438-48ac-b3e0-356a4b972235 | - |
| Incomplete dataset | - | consumers | - | - |
EFSA Study Results
Endpoint-level study rows from efsa_study_results matched to this substance.
| Endpoint | Species | Route | Effect | Assessment |
|---|---|---|---|---|
| sub-chronic toxicity: oral | rat | oral: feed | 23.4 other: | - |
| Carcinogenicity_EU_PPP | - | - | - | The Scientific Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aid was asked to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was requested to re-evaluate the flavouring substance in the Flavouring Group Evaluation 303Rev1, using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. The flavouring substance belongs to chemical group 30, Annex I of the Commission Regulation (EC) No 1565/2000. The present revision of FGE.303, FGE.303Rev1 includes a re-evaluation of spilanthol [FL-no: 16.121] as additional data, from a 90-day dietary rat study have become available. The candidate substance spilanthol [FL-no: 16.121] is a branched chain unsaturated aliphatic amide. The specifications provided specify the stereoisomeric composition. Spilanthol is assigned to structural class III, according to the decision tree approach presented by Cramer et al., 1978. |
| Carcinogenicity_EU_PPP | - | - | - | The Scientific Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) was asked to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was requested to evaluate one flavouring substance in the Flavouring Group Evaluation 303, using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. The flavouring substance belongs to chemical group 30, Annex I of the Commission Regulation (EC) No 1565/2000. The candidate substance spilanthol [FL-no: 16.121] is a branched chain unsaturated aliphatic amide from chemical group 30. |
| Genetic Toxicity | - | - | - | The Scientific Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) was asked to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was requested to evaluate one flavouring substance in the Flavouring Group Evaluation 303, using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. The flavouring substance belongs to chemical group 30, Annex I of the Commission Regulation (EC) No 1565/2000. The candidate substance spilanthol [FL-no: 16.121] is a branched chain unsaturated aliphatic amide from chemical group 30. |
| Genetic Toxicity | - | - | - | The Scientific Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aid was asked to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was requested to re-evaluate the flavouring substance in the Flavouring Group Evaluation 303Rev1, using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. The flavouring substance belongs to chemical group 30, Annex I of the Commission Regulation (EC) No 1565/2000. The present revision of FGE.303, FGE.303Rev1 includes a re-evaluation of spilanthol [FL-no: 16.121] as additional data, from a 90-day dietary rat study have become available. The candidate substance spilanthol [FL-no: 16.121] is a branched chain unsaturated aliphatic amide. The specifications provided specify the stereoisomeric composition. Spilanthol is assigned to structural class III, according to the decision tree approach presented by Cramer et al., 1978. |
Cross-Reference to Chemicals / Cosmetics / Food
Internal cross-vertical links connecting cannabis rows to chemical, cosmetics, and EFSA food/toxicology context.
Frequently Asked Questions
FAQ answers are generated from the same fetched cannabis, EFSA, cosmetics, and chemical rows rendered above.
What is the regulatory limit for Spilanthol in cannabis?
Spilanthol does not have a numeric cannabis_contaminant_tests range in the fetched page data. The current page query does not expose a separate action-limit column.
Which states test for Spilanthol?
Spilanthol does not have state-level cannabis testing rows in the fetched page data.
What are the EFSA reference values for Spilanthol?
Spilanthol has 4 EFSA OpenFoodTox reference value rows in the cannabis database, including TTC Cramer Class III, margin of safety, Incomplete dataset.
Is Spilanthol also regulated in cosmetics or food?
Spilanthol has a cosmetics ingredient cross-reference with EU status permitted. EFSA food/toxicology context is available on this page.