EFSA toxicology reference values
[3-(2,3-epoxypropoxy) propyl]trimethoxy silane
[3-(2,3-epoxypropoxy) propyl]trimethoxy silane (CAS 2530-83-8). Cannabis testing data across 0 states. Action levels when present, testing requirements, compliance status.
[3-(2,3-epoxypropoxy) propyl]trimethoxy silane is a cannabis analyte contaminant represented in the cannabis public dataset.
Substance Identity
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Contaminant Class Badge
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Dataset Snapshot
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EFSA Substance Identity
EFSA substance identity rows matched by chemical name or CAS.
EFSA Reference Values
Reference values from efsa_reference_values_v2 for toxicology and food-safety context.
| Descriptor | Value | Population | Endpoint | Body |
|---|---|---|---|---|
| margin of safety | - | consumers | - | - |
EFSA Study Results
Endpoint-level study rows from efsa_study_results matched to this substance.
| Endpoint | Species | Route | Effect | Assessment |
|---|---|---|---|---|
| in vitro gene mutation study in bacteria | - | - | - | The substance (purity not reported) dissolved in ethylene glycol dimethyl ether was tested for bacterial mutations in three strains of Salmonella Typhimurium TA97, TA98 and TA100 in triplicate plates with and without metabolic activation at concentrations up to 5,000 microg/plate. In TA100 strain, both in the absence or presence of S9 fraction, the test substance induced a statistically significant dose-related increase in the number of revertants. A statistically significant increase of the revertants was also observed in TA97 strain only at the highest concentration tested. No increase of revertants was detected in TA98 strain. |
| in vitro gene mutation study in mammalian cells | - | - | - | The substance (purity not specified) was tested for gene mutation in mouse lymphoma L5178Y cells up to 3,000 ng/mL in the absence and up to 8,000 ng/mL in the presence of metabolic activation system. In the absence of metabolic activation, a dose-dependent increase in mutation frequency, exceeding the Global Evaluation Factor at 3,000 ng/mL was observed. In the presence of metabolic activation, a dose-dependent increase in mutation frequency, exceeding the Global Evaluation Factor was detected at all the concentrations tested. Considering that the two criteria for evaluation and interpretation of results as positive on the basis of the OECD TG 490 were fulfilled: (i) an increase in mutation frequency above concurrent negative control, exceeding the Global Evaluation Factor, and (ii) a concentration-related effect, the test chemical is considered able to induce mutations in this test system. |
| in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus | mouse | intraperitoneal | - | The substance (100% pure) dissolved in water was administered as a single dose to mice at 500, 1,000 and 2,000 mg/kg bw. Animals were sacrificed at 24 and 48 h after the treatment. A statistically significant dose-related increase of micronucleated polychromatic erythrocyte (MNPCE) was observed in male and female mice 24 h after treatment at all dose levels with respect to the concurrent control values. A statistically significant increase of MNPCE was also observed in animals treated at 2,000 mg/kg bw and sampled at 48 h. Severe reductions in the ratio PCE/total erythrocytes were detected 48 h after treatment. |
| Carcinogenicity_EU_PPP | - | - | - | This scientific opinion of the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel) deals with the safety evaluation of [3-(2,3-epoxypropoxy)propyl] trimethoxy silane as a component for sizing glass fibres used for manufacturing glass-fibre-reinforced plastics. |
| Genetic Toxicity | - | - | - | This scientific opinion of the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel) deals with the safety evaluation of [3-(2,3-epoxypropoxy)propyl] trimethoxy silane as a component for sizing glass fibres used for manufacturing glass-fibre-reinforced plastics. |
| Genetic Toxicity | - | - | - | This scientific opinion of the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel) deals with the safety evaluation of [3-(2,3-epoxypropoxy)propyl] trimethoxy silane as a component for sizing glass fibres used for manufacturing glass-fibre-reinforced plastics. |
Cross-Reference to Chemicals / Cosmetics / Food
Internal cross-vertical links connecting cannabis rows to chemical, cosmetics, and EFSA food/toxicology context.
Frequently Asked Questions
FAQ answers are generated from the same fetched cannabis, EFSA, cosmetics, and chemical rows rendered above.
What is the regulatory limit for [3-(2,3-epoxypropoxy) propyl]trimethoxy silane in cannabis?
[3-(2,3-epoxypropoxy) propyl]trimethoxy silane does not have a numeric cannabis_contaminant_tests range in the fetched page data. The current page query does not expose a separate action-limit column.
Which states test for [3-(2,3-epoxypropoxy) propyl]trimethoxy silane?
[3-(2,3-epoxypropoxy) propyl]trimethoxy silane does not have state-level cannabis testing rows in the fetched page data.
What are the EFSA reference values for [3-(2,3-epoxypropoxy) propyl]trimethoxy silane?
[3-(2,3-epoxypropoxy) propyl]trimethoxy silane has 1 EFSA OpenFoodTox reference value row in the cannabis database, including margin of safety.
Is [3-(2,3-epoxypropoxy) propyl]trimethoxy silane also regulated in cosmetics or food?
[3-(2,3-epoxypropoxy) propyl]trimethoxy silane has a cosmetics ingredient cross-reference with EU status prohibited. EFSA food/toxicology context is available on this page.