EFSA toxicology reference values
beta-Ionone epoxide
beta-Ionone epoxide (CAS 23267-57-4). Cannabis testing data across 0 states. Action levels when present, testing requirements, compliance status.
beta-Ionone epoxide is a cannabis analyte contaminant represented in the cannabis public dataset.
Substance Identity
Analyte identity and classification used for this cannabis substance page.
Contaminant Class Badge
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Dataset Snapshot
Compact public-data summary for page quality, state coverage, lab rows, and potency sample groups.
EFSA Substance Identity
EFSA substance identity rows matched by chemical name or CAS.
EFSA Reference Values
Reference values from efsa_reference_values_v2 for toxicology and food-safety context.
| Descriptor | Value | Population | Endpoint | Body |
|---|---|---|---|---|
| TTC Cramer Class III | 1.5 µg/kg bw/day | consumers | - | - |
| TTC Cramer Class III | 1.5 µg/kg bw/day | consumers | - | - |
| TTC Cramer Class III | 1.5 µg/kg bw/day | consumers | - | other: |
| Incomplete dataset | - | consumers | - | - |
EFSA Study Results
Endpoint-level study rows from efsa_study_results matched to this substance.
| Endpoint | Species | Route | Effect | Assessment |
|---|---|---|---|---|
| boiling point | - | - | - | experimental study |
| appearance / physical state / colour | - | - | - | experimental study |
| solubility in organic solvents / fat solubility | - | - | - | experimental study |
| melting point/freezing point | - | - | - | Not reported |
| refractive index | - | - | - | experimental study |
| other: | - | - | - | experimental study |
| water solubility | - | - | - | experimental study |
| Carcinogenicity_EU_PPP | - | - | - | Following a request from the European Commission,the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel)was asked to deliver scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the CEF Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (theJECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217/EC and its consecutive amendments. |
| Carcinogenicity_EU_PPP | - | - | - | The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) was asked to provide scientific advise for the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was asked to evaluate flavouring substances using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. The present Flavouring Group Evaluation 210 (FGE.210) concerns 13 substances. The 13 substances correspond to subgroup 2.4 of FGE.19. Twelve of these substances are alpha,beta-unsaturated alicyclic ketones and one is a precursor for such ketones. |
| Carcinogenicity_EU_PPP | - | - | - | The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of 14 flavouring substances in Flavouring Group Evaluation 210 (FGE.210). |
| Carcinogenicity_EU_PPP | - | - | - | Following a request from the European Commission, the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) was asked to deliver a scientific opinion on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was asked to evaluate flavouring substances using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. The Flavouring Group Evaluation 210 (FGE.210) concerned 13 substances, belonging to subgroup 2.4 of FGE.19. Twelve of these substances are alpha,beta-unsaturated alicyclic ketones and one substance is a precursor for such ketone. The genotoxicity concern with respect to the 13 alpha,beta-unsaturated alicyclic ketones and precursors in FGE.210 could not be ruled out based on the genotoxicity data and (Quantitative) Structure-Activity Relationship ((Q)SAR) predictions available. The present revision of FGE.210 (FGE.210Revision1) has been prepared due to additional genotoxicity data submitted by the Industry on representative substances ( [FL-no: 07.007], [FL-no: 07.061], [FL-no: 07.170] and [FL-no: 07.134]). Also an additional substance has been included, cis-1-(2,6,6-trimethyl-2-cyclohexen-1-yl)but-2-en-1-one [FL-no: 07.225]. Beta-Ionone epoxide: GENOTOXICITY: beta-Ionone epoxide did not induce any significant increase in bacterial mutation when evaluated in five different S. typhimurium strains and an E. coli strain, either in the presence or absence of S9 metabolic activation in two independent studies. beta-Ionone epoxide also did not increase mutation frequencies when tested in a tk mutation assay using mouse lymphoma cells either in the presence or absence of S9 metabolic activation. OUTCOME ON THE NAMED COMPOUND (JECFA, 1999; JECFA, 2006): Not evaluated by JECFA. OUTCOME ON THE MATERIAL OF COMMERCE: Evaluated in FGE.210Rev1, genotoxicity concern could be ruled out. Can be evaluated using the procedure. |
| Genetic Toxicity | - | - | - | The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of 14 flavouring substances in Flavouring Group Evaluation 210 (FGE.210). |
Cross-Reference to Chemicals / Cosmetics / Food
Internal cross-vertical links connecting cannabis rows to chemical, cosmetics, and EFSA food/toxicology context.
Frequently Asked Questions
FAQ answers are generated from the same fetched cannabis, EFSA, cosmetics, and chemical rows rendered above.
What is the regulatory limit for beta-Ionone epoxide in cannabis?
beta-Ionone epoxide does not have a numeric cannabis_contaminant_tests range in the fetched page data. The current page query does not expose a separate action-limit column.
Which states test for beta-Ionone epoxide?
beta-Ionone epoxide does not have state-level cannabis testing rows in the fetched page data.
What are the EFSA reference values for beta-Ionone epoxide?
beta-Ionone epoxide has 4 EFSA OpenFoodTox reference value rows in the cannabis database, including TTC Cramer Class III, Incomplete dataset.
Is beta-Ionone epoxide also regulated in cosmetics or food?
beta-Ionone epoxide has a cosmetics ingredient cross-reference with EU status permitted. EFSA food/toxicology context is available on this page.