Toluene-2,5-diamine and its sulfate: What the SCCS Concluded About Safety in Cosmetics
Toluene-2,5-diamine and its sulfate safety summary from SCCS/1479/12: SCCS conclusion, NOAEL, maximum concentration or conditions, and source-linked conte.
Toluene-2,5-diamine and its sulfate is covered by SCCS/1479/12, an SCCS-family cosmetic safety opinion dated 2012-06-27. The opinion conclusion for this opinion is direct enough for a substance-specific summary: Using the conventional risk assessment approach, a Margin of Safety of 18 was calculated. However, using a toxicokinetics-based approach based on a new human exposure study in vivo the Margin of Safety was calculated using the area under the curve.
Core Opinion Facts
- Opinion: SCCS/1479/12
- Opinion date: 2012-06-27
- Primary substance: Toluene-2,5-diamine and its sulfate
NOAEL Values Cited in the Opinion
The no-observed-adverse-effect data below is shown only from the SCCS source fields for this opinion. It is not a calculated margin-of-safety output.
| Endpoint | Value | Unit | Study context |
|---|---|---|---|
| NOAEL | 10 | mg/kg bw/d | rat, oral, gavage, 91 consecutive days + 28-day recovery (control and high dose only) |
| NOAEL | 2.5 | mg/kg bw/d | rat, oral, gavage, 13 weeks |
| reproductive toxicity | 45 | mg/kg bw/d | rat, reproductive toxicity (two-generation) |
Maximum Concentration or Conditions
Conditions from the Opinion
Using the conventional risk assessment approach, a Margin of Safety of 18 was calculated. However, using a toxicokinetics-based approach based on a new human exposure study in vivo the Margin of Safety was calculated using the area under the curve.
How to Read This Safety Conclusion
The key point for formulators is the match between the named ingredient, the cited NOAEL, and the SCCS conclusion. A NOAEL is a study point of departure, not a standalone permission to use Toluene-2,5-diamine and its sulfate at any level. The SCCS conclusion and any concentration or product-type conditions remain the controlling context for cosmetic use.
The source also matters because SCCS opinions can be ingredient-specific. The internal ingredient page for Toluene-2,5-diamine and its sulfate should be treated as the substance hub, while SCCS/1479/12 is the opinion-level page for the committee record.
Practical Formulation Takeaway
For a formula review, start with the identity check: confirm the INCI name, CAS number, and opinion reference align with the material in the formula. Then compare the intended product type against the SCCS concentration or condition language above. If the formulation uses a different exposure route, product category, or concentration basis, the SCCS conclusion should not be stretched beyond what SCCS/1479/12 actually assessed.
Review Notes
The conservative reading is to keep Toluene-2,5-diamine and its sulfate tied to this exact opinion. The opinion number, date, NOAEL table, and condition language all travel together. If a later formula review uses a different CAS identity, product type, or concentration basis, the source should be checked again rather than reusing this summary as a blanket answer.
This page is therefore an indexable safety summary, not a replacement for the committee text. It gives search readers the core SCCS facts for Toluene-2,5-diamine and its sulfate and keeps the source handle visible for audit.
Source
- SCCS opinion: SCCS/1479/12
- Source file: sccs_o_093.pdf
- Extraction JSON: SCCS Scientific Opinions