Soytrimonium chloride: What the SCCS Concluded About Safety in Cosmetics
Soytrimonium chloride safety summary from SCCS/1464/12: SCCS conclusion, NOAEL, maximum concentration or conditions, and source-linked context.
Soytrimonium chloride is covered by SCCS/1464/12, an SCCS-family cosmetic safety opinion dated 2012-03-27. The opinion conclusion for this opinion is direct enough for a substance-specific summary: The final evaluation of the safety of Soytrimonium Chloride for the intended uses of non-oxidative and oxidative conditions of hair dyeing is not possible due to some missing data and studies: - No information on the irritant potential of Soytrimonium chloride under oxidative conditions in skin is available. Appropriate studies with oxidised soytrimonium chloride would be required to determine irritant potential.
Core Opinion Facts
- Opinion: SCCS/1464/12
- Opinion date: 2012-03-27
- Primary substance: Soytrimonium chloride
- CAS: 61790-41-8
NOAEL Values Cited in the Opinion
The no-observed-adverse-effect data below is shown only from the SCCS source fields for this opinion. It is not a calculated margin-of-safety output.
| Endpoint | Value | Unit | Study context |
|---|---|---|---|
| NOAEL | 100 mg/kg bw/day | Sprague Dawley rat, 28-day repeated dose oral toxicity (rat) | |
| systemic effects | 10 mg/kg bw/day | New Zealand albino rabbit, 28-day dermal administration (rabbit) | |
| NOAEL | 10 mg/kg bw/day | Sprague Dawley rat, Chronic (12 months) oral toxicity (rat) |
Maximum Concentration or Conditions
Conditions from the Opinion
The final evaluation of the safety of Soytrimonium Chloride for the intended uses of non-oxidative and oxidative conditions of hair dyeing is not possible due to some missing data and studies: - No information on the irritant potential of Soytrimonium chloride under oxidative conditions in skin is available.
How to Read This Safety Conclusion
The key point for formulators is the match between the named ingredient, the cited NOAEL, and the SCCS conclusion. A NOAEL is a study point of departure, not a standalone permission to use Soytrimonium chloride at any level. The SCCS conclusion and any concentration or product-type conditions remain the controlling context for cosmetic use.
The source also matters because SCCS opinions can be ingredient-specific. The internal ingredient page for Soytrimonium chloride should be treated as the substance hub, while SCCS/1464/12 is the opinion-level page for the committee record.
Practical Formulation Takeaway
For a formula review, start with the identity check: confirm the INCI name, CAS number, and opinion reference align with the material in the formula. Then compare the intended product type against the SCCS concentration or condition language above. If the formulation uses a different exposure route, product category, or concentration basis, the SCCS conclusion should not be stretched beyond what SCCS/1464/12 actually assessed.
Source
- SCCS opinion: SCCS/1464/12
- Source file: sccs_o_091.pdf
- Extraction JSON: SCCS Scientific Opinions