Ethylhexyl Methoxycinnamate (EHMC): What the SCCS Concluded About Safety in Cosmetics
Ethylhexyl Methoxycinnamate (EHMC) safety summary from SCCS/1671/24: SCCS conclusion, NOAEL, maximum concentration or conditions, and source-linked contex.
Ethylhexyl Methoxycinnamate (EHMC) is covered by SCCS/1671/24, an SCCS-family cosmetic safety opinion dated 2025-06-26. The opinion conclusion for this opinion is direct enough for a substance-specific summary: The SCCS has noted that the available evidence shows that EHMC is an endocrine-active substance due to estrogenic activity and weak anti-androgenic activity both in vitro and in vivo.
Core Opinion Facts
- Opinion: SCCS/1671/24
- Opinion date: 2025-06-26
- Primary substance: Ethylhexyl Methoxycinnamate (EHMC)
- CAS: 5466-77-3
NOAEL Values Cited in the Opinion
The no-observed-adverse-effect data below is shown only from the SCCS source fields for this opinion. It is not a calculated margin-of-safety output.
| Endpoint | Value | Unit | Study context |
|---|---|---|---|
| systemic_NOAEL_13wk_oral | 450 | mg/kg bw/day | rat, oral (feed), 13 weeks (OECD TG 408) |
| 2_generation_reproductive_parental_offspring_NOAEL | 450 | mg/kg bw/day | rat, oral (feed), 2-generation (OECD TG 416) |
| developmental_toxicity_rat_oral | 1000 | mg/kg bw/day | rat, oral (gavage), GD 6-14 (prenatal) |
Maximum Concentration or Conditions
| Use condition | Value | Unit |
|---|---|---|
| Maximum concentration | 10 | % |
| Sunscreen lotion (dermal) | 10.0 | % |
| Face cream | 10.0 | % |
| Hand cream | 10.0 | % |
| Lipstick | 10.0 | % |
| Sunscreen propellant spray | 10.0 | % |
| Sunscreen pump spray | 10.0 | % |
Conditions from the Opinion
UV filter only. Annex VI/12 already permits 10% max; opinion confirms 10% remains safe despite EDC concerns.
How to Read This Safety Conclusion
The key point for formulators is the match between the named ingredient, the cited NOAEL, and the SCCS conclusion. A NOAEL is a study point of departure, not a standalone permission to use Ethylhexyl Methoxycinnamate (EHMC) at any level. The SCCS conclusion and any concentration or product-type conditions remain the controlling context for cosmetic use.
The source also matters because SCCS opinions can be ingredient-specific. The internal ingredient page for Ethylhexyl Methoxycinnamate (EHMC) should be treated as the substance hub, while SCCS/1671/24 is the opinion-level page for the committee record.
Practical Formulation Takeaway
For a formula review, start with the identity check: confirm the INCI name, CAS number, and opinion reference align with the material in the formula. Then compare the intended product type against the SCCS concentration or condition language above. If the formulation uses a different exposure route, product category, or concentration basis, the SCCS conclusion should not be stretched beyond what SCCS/1671/24 actually assessed.
Review Notes
The conservative reading is to keep Ethylhexyl Methoxycinnamate (EHMC) tied to this exact opinion. The opinion number, date, NOAEL table, and condition language all travel together. If a later formula review uses a different CAS identity, product type, or concentration basis, the source should be checked again rather than reusing this summary as a blanket answer.
This page is therefore an indexable safety summary, not a replacement for the committee text. It gives search readers the core SCCS facts for Ethylhexyl Methoxycinnamate (EHMC) and keeps the source handle visible for audit.
Source
- SCCS opinion: SCCS/1671/24
- Source file: sccs_o_294.pdf
- Extraction JSON: SCCS Scientific Opinions