PEGylated Alkyl Glycerides: CIR Safety Assessment Summary
CIR safety assessment summary for PEGylated Alkyl Glycerides: ingredients reviewed, panel verdict, use concentration context, conditions, and source citat.
PEGylated Alkyl Glycerides appears in a CIR safety assessment covering PEGylated Alkyl Glycerides. The panel verdict for the report is safe with restrictions. Summary Reference Triethylene Glycol and Polyethylene Glycols (PEGs) > 4 Safe for use in cosmetics in the present practices of use and concentration In general, PEGs are not oral toxicants, with acute oral LD50 values in rodents ranging from 15-22 g/kg. The LC50 of aerosolized triethylene glycol in rats was greater than 3.9 mg/L.
| Field | CIR value |
|---|---|
| Primary ingredient | PEGylated Alkyl Glycerides |
| CIR verdict | safe with restrictions |
| Report type | Safety Assessment |
| Date | 2020 |
| CAS numbers | 124046-50-0, 103819-44-9, 361459-38-3, 67762-35-0, 66105-29-1, 68201-46-7 |
| Use concentration context | 5%; 13%; >50%; 4% |
| Conditions or carve-outs | Summary Reference Triethylene Glycol and Polyethylene Glycols (PEGs) > 4 Safe for use in cosmetics in the present practices of use and concentration In general, PEGs are not oral toxicants, with acute oral LD50 values in rodents ranging from 15-22 g/kg. |
Ingredients Reviewed
The review scope matters because CIR conclusions often apply to an ingredient family rather than a single INCI name. In this report, the ingredient list includes PEGylated Alkyl Glycerides.
Safety Conclusion
The conclusion for PEGylated Alkyl Glycerides should be read as a CIR panel conclusion, not a regulatory limit. CIR assessments summarize expert-panel safety determinations for cosmetic use, while legal status still depends on the jurisdiction and product category.
For use levels, the report gives this concentration context: 5%; 13%; >50%; 4%. That language is the safe-use context shown for this page.
Formulation Reading
For formula review, begin with the exact INCI identity and the ingredient group covered by the CIR assessment. If the material is PEGylated Alkyl Glycerides, the relevant comparison is whether the intended use aligns with the practices, concentration ranges, and conditions described in the CIR source.
The ingredient hub at PEGylated Alkyl Glycerides should carry the substance-level profile. This page is the report-level summary, keeping the conclusion, ingredient scope, and use-context language attached to the CIR source rather than treating the conclusion as a universal permission.
Why This Page Exists
CIR reviews are long documents, and the practical answer is usually buried in the conclusion and the table of current practices. This summary keeps those CIR facts in one indexable page for PEGylated Alkyl Glycerides, with source details retained at the bottom for audit.
Source
- CIR report: Safety Assessment of PEGylated Alkyl Glycerides as Used in Cosmetics Monice M. Fiume*, Wilma F. Bergfeld**, Donald V. Belsito**, Ronald A. Hill**, Curtis D. Klaassen**, Daniel C. Liebler**, James G. Marks, Jr.**, Ronald C. Shank**, Thomas J
- CIR source file: PRS681.pdf
- Extraction JSON: Source documentation archived.
- Conclusion page in CIR extraction: 9