CIR Review Summary May 6, 2026 3 min read

4-Nitro-o-Phenylenediamine: CIR Safety Assessment Summary

CIR safety assessment summary for 4-Nitro-o-Phenylenediamine: ingredients reviewed, panel verdict, use concentration context, conditions, and source citat.

4-Nitro-o-Phenylenediamine appears in a CIR safety assessment covering 4-Nitro-o-Phenylenediamine. The panel verdict for the report is safe. The Expert Panel for Cosmetic Ingredient Safety concluded that 4-Nitro-o-Phenylenediamine is safe for use as a hair dye ingredient in the present practices of use and concentrations described in this safety assessment. TABLES Table 1.

FieldCIR value
Primary ingredient4-Nitro-o-Phenylenediamine
CIR verdictsafe
Report typeFinal Amended Report
Date9 In 2023
CAS numbers99-56-9
Use concentration contextpresent practices of use and concentration described in the safety assessment
Conditions or carve-outs

Ingredients Reviewed

The review scope matters because CIR conclusions often apply to an ingredient family rather than a single INCI name. In this report, the ingredient list includes 4-Nitro-o-Phenylenediamine.

Safety Conclusion

The conclusion for 4-Nitro-o-Phenylenediamine should be read as a CIR panel conclusion, not a regulatory limit. CIR assessments summarize expert-panel safety determinations for cosmetic use, while legal status still depends on the jurisdiction and product category.

For use levels, the report gives this concentration context: present practices of use and concentration described in the safety assessment. That language is the safe-use context shown for this page.

Conditions

The Expert Panel for Cosmetic Ingredient Safety concluded that 4-Nitro-o-Phenylenediamine is safe for use as a hair dye ingredient in the present practices of use and concentrations described in this safety assessment.

Formulation Reading

For formula review, begin with the exact INCI identity and the ingredient group covered by the CIR assessment. If the material is 4-Nitro-o-Phenylenediamine, the relevant comparison is whether the intended use aligns with the practices, concentration ranges, and conditions described in the CIR source.

The ingredient hub at 4-Nitro-o-Phenylenediamine should carry the substance-level profile. This page is the report-level summary, keeping the conclusion, ingredient scope, and use-context language attached to the CIR source rather than treating the conclusion as a universal permission.

Why This Page Exists

CIR reviews are long documents, and the practical answer is usually buried in the conclusion and the table of current practices. This summary keeps those CIR facts in one indexable page for 4-Nitro-o-Phenylenediamine, with source details retained at the bottom for audit.

Review Notes

The conservative reading is to keep 4-Nitro-o-Phenylenediamine tied to the exact CIR report listed below. The ingredient family, panel conclusion, date, and any use-condition language belong together. A shorter ingredient-page snippet would lose that context.

This page gives the search-level answer while preserving the source-level caveat: CIR safety language is a panel assessment for cosmetic practices of use, not a universal legal permission across every jurisdiction or product category.


Source

  • CIR report: Amended Safety Assessment of 4-Nitro-o-Phenylenediamine as Used in Cosmetics Status: Final Amended Report Release Date:
  • CIR source file: fr925.pdf
  • Extraction JSON: Source documentation archived.
  • Conclusion page in CIR extraction: 10