Is Dihydroergotamine safe in cosmetics?
Dihydroergotamine has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.
Poor
Cosmetic Ingredient
Dihydroergotamine
INCI: DIHYDROERGOTAMINE
Dihydroergotamine (CAS 6190-39-2) is a cosmetic cosmetic ingredient functioning as Not for cosmetic use. EU Regulation 1223/2009 status: prohibited.
CAS Number
6190-39-2
Function
Not for cosmetic use
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
(6aR,9R,10aR)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide;methanesulfonic acid
InChIKey
ADYPXRFPBQGGAH-UMYZUSPBSA-N
Regulatory Status
🇪🇺 EU Status
prohibited
🇺🇸 US Status
prohibited
US Notes
Pharmaceutical drug (ergot alkaloid); not approved for cosmetic use in the US
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dihydroergotamine - available to Pro subscribers.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Expert Verdict
Expert safety assessment and concern-level summary for Dihydroergotamine - available to Pro subscribers.
Regulatory Flags
pharmaceutical
prohibited-EU
not-cosmetic
ergot-alkaloid
prop65
Frequently Asked Questions
Is Dihydroergotamine allowed in the EU?
Dihydroergotamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydroergotamine do in cosmetics?
Dihydroergotamine functions as: Not for cosmetic use. It is classified as a cosmetic ingredient in our database. CAS number: 6190-39-2.
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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