Food Safety Substance

Calcium D-gluconateE578

Calcium D-gluconate (E578) is a food additive with PUBLISHED in the EU, FDA has no questions in the US, and data from 6 regulatory sources.

CAS 299-28-5 E578 Indexable evidence set

FDA

FDA has no questions

ADI / TDI

ADI NOT SPECIFIED mg/kg bw

Codex

1 row(s)

SOURCE D1 identity resolution e number aliases | Food Additives | dsstox identifiers | 6 matched regulatory source group(s)

Substance Identity

Resolved identifiers used to render this food-safety record.

Substance name

Calcium D-gluconate

CAS

299-28-5

E-number

E578

DTXSID

DTXSID2029618

PubChem CID

9290

Evidence tier

Indexable evidence set (11)

SOURCE EU Commission FDA | Health Canada | Codex Alimentarius

Multi-Jurisdiction Comparison

Side-by-side status rows for the same resolved substance across public food regulators.

Jurisdiction	Authority	Status	Evidence
European Union	EU Commission	PUBLISHED	EU additive listing; Annex II entry
United States	FDA	FDA has no questions	GRAS notice
Codex	Codex Alimentarius	Listed	Acidity regulator; Firming agent; Sequestrant

SOURCE EU Commission EU Food Additives | EU Food Additives Database

EU Food Additive Status

EU Commission food-additive listing rows from eu_food_additives.

Jurisdiction	E-number	Status	Type	Name	Note
European Union	E578	PUBLISHED	substanceFAD	Calcium gluconate	-

SOURCE EU Commission EU Annex II Authorised | EU Food Additives Database

EU Annex II Authorised Uses

Authorised additive rows and use conditions from EU Annex II tables.

Jurisdiction	E-number	Name	INS	Policy item	Note
European Union	E578	Calcium gluconate	-	POL-FAD-IMPORT-3248	-

Conditions and restrictions

Jurisdiction	Food category	Restriction	Comment	Source
European Union	11.4.2 table-top sweeteners in powder form	quantum satis	-	EU Annex II Union List
European Union	11.4.3 table-top sweeteners in tablets	quantum satis	-	EU Annex II Union List
European Union	11.4.2 table-top sweeteners in powder form	quantum satis	-	EU Food Additives Database
European Union	11.4.3 table-top sweeteners in tablets	quantum satis	-	EU Food Additives Database

SOURCE Codex Alimentarius Codex GSFA

Codex GSFA Status

Codex Alimentarius GSFA permissions and maximum-use rows.

Jurisdiction	INS / E-number	Function	Food category	Max level	Notes
Codex	578	Acidity regulator; Firming agent; Sequestrant	Table 3 Foods in General (GMP)	GMP	Table 3 additive - GMP in foods in general

SOURCE FDA FDA GRAS

FDA GRAS Status

US FDA GRAS notice evidence from enriched and notice tables.

Jurisdiction	GRN	Substance	FDA response	Intended use	Basis	Notifier
United States	136	Calcium gluconate	FDA has no questions	Use in food in general as a source of calcium	Scientific procedures	Purac Biochem b.v.

SOURCE JECFA JECFA ADI

JECFA ADI Values

JECFA ADI records and evaluation years.

Jurisdiction	Chemical name	JECFA no.	CAS	ADI	ADI upper	Function	Evaluation year
JECFA	CALCIUM GLUCONATE	-	299-28-5	NOT SPECIFIED	-	ACIDITY_REGULATOR, FIRMING_AGENT, NUTRIENT_SUPPLEMENT, SEQUESTRANT	1998

SOURCE ingredients ghs classifications

Cross-Reference to Cosmetics / Chemicals / Pharma

Same-CAS public rows from adjacent Roots verticals where available.

SOURCE Cross-vertical comparison ingredients | ghs classifications

Cross-Vertical Regulatory Divergence

This substance has different regulatory treatment across food, cosmetics, and industrial use.

CosmeticsCalcium GluconateEU status: permitted Industrial / GHSGHS row foundEuropean Chemicals Agency (ECHA)

SOURCE FAQPage JSON-LD public food renderer rows

Frequently Asked Questions

Food-use, safety, ADI, and cross-vertical answers mirrored into FAQPage JSON-LD.

What is Calcium D-gluconate used for in food?

Calcium D-gluconate appears in food-use rows as: Sequestrant/Firming agent; Acidity regulator; Firming agent; Sequestrant.

Is Calcium D-gluconate / E578 safe?

This page does not assign a standalone safety verdict; it renders public regulatory evidence. ADI/reference value: ADI NOT SPECIFIED mg/kg bw. EU status evidence: PUBLISHED. US/FDA evidence: FDA has no questions.

What is the ADI for Calcium D-gluconate?

Calcium D-gluconate has this ADI/reference value in the food-safety tables: ADI NOT SPECIFIED mg/kg bw. Source: WHO JECFA.

Is Calcium D-gluconate also used in cosmetics?

Calcium D-gluconate has a same-CAS cosmetics cross-reference: Calcium Gluconate, EU status permitted.