Food Safety Substance
Ethyl-N2-dodecanoyl-L-argininate hydrochlorideE243
Ethyl-N2-dodecanoyl-L-argininate hydrochloride (E243) is a food additive with PUBLISHED in the EU, FDA has no questions in the US, and data from 8 regulatory sources.
CAS 60372-77-2
E243
Indexable evidence set
FDA
FDA has no questions
ADI / TDI
ADI 0.5 mg/kg bw/day
Codex
39 row(s)
SOURCE
D1 identity resolution
e number aliases | Food Additives | dsstox identifiers | 8 matched regulatory source group(s)
Substance Identity
Resolved identifiers used to render this food-safety record.
Substance name
Ethyl-N2-dodecanoyl-L-argininate hydrochloride
CAS
60372-77-2
E-number
E243
DTXSID
DTXSID40209136
PubChem CID
25229630
Evidence tier
Indexable evidence set (13)
SOURCE
EU Commission
FDA | Health Canada | Codex Alimentarius
Multi-Jurisdiction Comparison
Side-by-side status rows for the same resolved substance across public food regulators.
| Jurisdiction | Authority | Status | Evidence |
|---|---|---|---|
| European Union | EU Commission | PUBLISHED | EU additive listing; Annex II entry |
| United States | FDA | FDA has no questions | GRAS notice |
| Codex | Codex Alimentarius | Listed | Preservative |
SOURCE
EU Commission
EU Food Additives | EU Food Additives Database
EU Food Additive Status
EU Commission food-additive listing rows from eu_food_additives.
| Jurisdiction | E-number | Status | Type | Name | Note |
|---|---|---|---|---|---|
| European Union | E243 | PUBLISHED | substanceFAD | Ethyl lauroyl arginate | - |
SOURCE
EU Commission
EU Annex II Authorised | EU Food Additives Database
EU Annex II Authorised Uses
Authorised additive rows and use conditions from EU Annex II tables.
| Jurisdiction | E-number | Name | INS | Policy item | Note |
|---|---|---|---|---|---|
| European Union | E243 | Ethyl lauroyl arginate | - | POL-FAD-IMPORT-3349 | - |
Conditions and restrictions
| Jurisdiction | Food category | Restriction | Comment | Source |
|---|---|---|---|---|
| European Union | 8.3.2 Heat-treated processed meat | ML 160 mg/kg | except emulsified sausages, smoked sausages and liver paste | EU Annex II Union List |
| European Union | 8.3.2 Heat-treated processed meat | ML 160 mg/kg | except emulsified sausages, smoked sausages and liver paste | EU Food Additives Database |
SOURCE
Codex Alimentarius
Codex GSFA
Codex GSFA Status
Codex Alimentarius GSFA permissions and maximum-use rows.
| Jurisdiction | INS / E-number | Function | Food category | Max level | Notes |
|---|---|---|---|---|---|
| Codex | 243 | Preservative | 01.6.1 Unripened cheese | 200 mg/kg | - |
| Codex | 243 | Preservative | 01.6.2.1 Ripened cheese, includes rind | 200 mg/kg | Excluding products conforming to the Standard for Brie (CXS 277-1973).; Excluding products conforming to the Standard for Coulommiers (CXS 274-1969).; Excluding products... |
| Codex | 243 | Preservative | 01.6.3 Whey cheese | 200 mg/kg | - |
| Codex | 243 | Preservative | 01.6.4 Processed cheese | 200 mg/kg | - |
| Codex | 243 | Preservative | 01.6.5 Cheese analogues | 200 mg/kg | - |
| Codex | 243 | Preservative | 01.7 Dairy-based desserts (e.g. pudding, fruit or flavoured yoghurt) | 200 mg/kg | Excluding products conforming to the Standard for Fermented Milks (CXS 243-2003). |
| Codex | 243 | Preservative | 02.2.2 Fat spreads, dairy fat spreads and blended spreads | 200 mg/kg | Excluding products conforming to the Standard for Fat Spreads and Blended Spreads (CXS 256-2007).; Excluding products conforming to the Standard for Dairy Fat Spreads (CXS... |
| Codex | 243 | Preservative | 04.1.2.11 Fruit fillings for pastries | 200 mg/kg | - |
| Codex | 243 | Preservative | 04.1.2.2 Dried fruit | 200 mg/kg | - |
| Codex | 243 | Preservative | 04.2.1.2 Surface-treated fresh vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds, and nuts and seeds | 200 mg/kg | - |
| Codex | 243 | Preservative | 04.2.1.3 Peeled, cut or shredded fresh vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds, and nuts and seeds | 200 mg/kg | - |
| Codex | 243 | Preservative | 04.2.2.3 Vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), and seaweeds in vinegar, oil, brine, or soybean sauce | 200 mg/kg | - |
| Codex | 243 | Preservative | 05.1.3 Cocoa-based spreads, including fillings | 200 mg/kg | Excluding products conforming to the Standard for Cocoa Butter (CODEX STAN 86-1981). |
| Codex | 243 | Preservative | 05.3 Chewing gum | 225 mg/kg | - |
| Codex | 243 | Preservative | 06.5 Cereal and starch based desserts (e.g. rice pudding, tapioca pudding) | 200 mg/kg | - |
| Codex | 243 | Preservative | 08.2.1 Non-heat treated processed meat, poultry, and game products in whole pieces or cuts | 200 mg/kg | - |
| Codex | 243 | Preservative | 08.2.2 Heat-treated processed meat, poultry, and game products in whole pieces or cuts | 200 mg/kg | For products conforming to the Standard for Cooked Cured Ham (CODEX STAN 96-1981) and the Standard for Cooked Cured Pork Shoulder (CODEX STAN 97-1981), use is limited to... |
| Codex | 243 | Preservative | 08.2.3 Frozen processed meat, poultry, and game products in whole pieces or cuts | 200 mg/kg | For use in surface treatment only.; For use in cooked frozen meat products only. |
| Codex | 243 | Preservative | 08.3.1 Non-heat treated processed comminuted meat, poultry, and game products | 315 mg/kg | - |
| Codex | 243 | Preservative | 08.3.2 Heat-treated processed comminuted meat, poultry, and game products | 200 mg/kg | For products conforming to the Standard for Luncheon Meat (CODEX STAN 89-1981), Standard for Cooked Cured Chopped Meat (CODEX STAN 98-1981), and Standard for Corned Beef (CODEX... |
| Codex | 243 | Preservative | 08.3.3 Frozen processed comminuted meat, poultry, and game products | 315 mg/kg | For use in surface treatment only.; For use in cooked frozen meat products only. |
| Codex | 243 | Preservative | 09.2.4.1 Cooked fish and fish products | 200 mg/kg | - |
| Codex | 243 | Preservative | 09.2.4.2 Cooked mollusks, crustaceans, and echinoderms | 200 mg/kg | - |
| Codex | 243 | Preservative | 09.2.4.3 Fried fish and fish products, including mollusks, crustaceans, and echinoderms | 200 mg/kg | For use only in ready-to-eat products that require refrigeration. |
| Codex | 243 | Preservative | 09.2.5 Smoked, dried, fermented, and/or salted fish and fish products, including mollusks, crustaceans, and echinoderms | 200 mg/kg | Excluding products conforming to the Standard for Boiled Dried Salted Anchovies (CODEX STAN 236-2003).; Excluding products conforming to the Standard for Dried Shark Fins (CODEX... |
| Codex | 243 | Preservative | 09.3.1 Fish and fish products, including mollusks, crustaceans, and echinoderms, marinated and/or in jelly | 200 mg/kg | - |
| Codex | 243 | Preservative | 09.3.2 Fish and fish products, including mollusks, crustaceans, and echinoderms, pickled and/or in brine | 200 mg/kg | - |
| Codex | 243 | Preservative | 09.3.3 Salmon substitutes, caviar, and other fish roe products | 200 mg/kg | Excluding products conforming to the Standard for Sturgeon Caviar (CODEX STAN 291-2010). |
| Codex | 243 | Preservative | 09.3.4 Semi-preserved fish and fish products, including mollusks, crustaceans, and echinoderms (e.g. fish paste), excluding products of food categories 09.3.1 - 09.3.3 | 200 mg/kg | - |
| Codex | 243 | Preservative | 10.2 Egg products | 200 mg/kg | - |
| Codex | 243 | Preservative | 10.4 Egg-based desserts (e.g. custard) | 200 mg/kg | - |
| Codex | 243 | Preservative | 12.2.2 Seasonings and condiments | 200 mg/kg | - |
| Codex | 243 | Preservative | 12.5 Soups and broths | 200 mg/kg | Excluding products conforming to the Codex Standard for Bouillons and Consommés (CODEX STAN 117-1981). |
| Codex | 243 | Preservative | 12.6.1 Emulsified sauces and dips (e.g. mayonnaise, salad dressing, onion dip) | 200 mg/kg | - |
| Codex | 243 | Preservative | 12.6.2 Non-emulsified sauces (e.g. ketchup, cheese sauce, cream sauce, brown gravy) | 200 mg/kg | Excluding products conforming to the Standard for Chilli Sauce (CXS 306-2011). |
| Codex | 243 | Preservative | 12.7 Salads (e.g. macaroni salad, potato salad) and sandwich spreads excluding cocoa- and nut-based spreads of food categories 04.2.2.5 and 05.1.3 | 200 mg/kg | - |
| Codex | 243 | Preservative | 14.1.4.1 Carbonated water-based flavoured drinks | 50 mg/kg | - |
| Codex | 243 | Preservative | 14.1.4.2 Non-carbonated water-based flavoured drinks, including punches and ades | 50 mg/kg | - |
| Codex | 243 | Preservative | 14.1.4.3 Concentrates (liquid or solid) for water-based flavoured drinks | 50 mg/kg | On the served to the consumer basis. |
SOURCE
FDA
FDA GRAS
FDA GRAS Status
US FDA GRAS notice evidence from enriched and notice tables.
| Jurisdiction | GRN | Substance | FDA response | Intended use | Basis | Notifier |
|---|---|---|---|---|---|---|
| United States | 164 | Lauramide arginine ethyl ester | FDA has no questions | Antimicrobial ingredient added directly to food, including meat and poultry | Scientific procedures | Laboratorios Miret, S.A. (LAMIRSA) |
SOURCE
JECFA
JECFA ADI
JECFA ADI Values
JECFA ADI records and evaluation years.
| Jurisdiction | Chemical name | JECFA no. | CAS | ADI | ADI upper | Function | Evaluation year |
|---|---|---|---|---|---|---|---|
| JECFA | ETHYL LAUROYL ARGINATE | - | 60372-77-2 | 0-4 mg/kg bw | 4 | PRESERVATIVE | 2008 |
SOURCE
ingredients
ghs classifications
Cross-Reference to Cosmetics / Chemicals / Pharma
Same-CAS public rows from adjacent Roots verticals where available.
SOURCE
Cross-vertical comparison
ingredients | ghs classifications
Cross-Vertical Regulatory Divergence
This substance has different regulatory treatment across food, cosmetics, and industrial use.
SOURCE
FAQPage JSON-LD
public food renderer rows
Frequently Asked Questions
Food-use, safety, ADI, and cross-vertical answers mirrored into FAQPage JSON-LD.
What is Ethyl-N2-dodecanoyl-L-argininate hydrochloride used for in food?
Ethyl-N2-dodecanoyl-L-argininate hydrochloride appears in food-use rows as: Preservative; Preservative.
Is Ethyl-N2-dodecanoyl-L-argininate hydrochloride / E243 safe?
This page does not assign a standalone safety verdict; it renders public regulatory evidence. ADI/reference value: ADI 0.5 mg/kg bw/day. EU status evidence: PUBLISHED. US/FDA evidence: FDA has no questions.
What is the ADI for Ethyl-N2-dodecanoyl-L-argininate hydrochloride?
Ethyl-N2-dodecanoyl-L-argininate hydrochloride has this ADI/reference value in the food-safety tables: ADI 0.5 mg/kg bw/day. Source: food_substances.
Is Ethyl-N2-dodecanoyl-L-argininate hydrochloride also used in cosmetics?
Ethyl-N2-dodecanoyl-L-argininate hydrochloride has a same-CAS cosmetics cross-reference: Ethyl Lauroyl Arginate HCl, EU status restricted.